Poly(acrylic acid)-Assisted Intrafibrillar Mineralization of Type I Collagen: A Review

Chen, Lei1; Zeng, Zhiyong2; Li, Wenbing2

2023-02-01

10.1002/marc.202200827

MACROMOLECULAR RAPID COMMUNICATIONS   影响因子和分区

1022-1336

1521-3927

The mineralization of type I collagen is a biological process occurring in vertebrates by which some hard tissues such as bone and dentin are constructed. Due to the extensive clinical needs for bone defect repair and remineralization of mineral-depleted dentin, biomimetic mineralization of collagen is attracting more and more interests. Synthetic analogs of noncollagenous proteins are necessary for directing the in vitro mineralization. In this paper, the function and mechanism of poly(acrylic acid) (PAA) in regulating the mineralization, especially intrafibrillar mineralization (IM) of collagen are reviewed. As two mineralization patterns (extrafibrillar and intrafibrillar) co-exist in natural hard tissues, differences between them in terms of microstructure, biodegradation, cytocompatibility, osteoinduction in vitro, and performance in vivo are systematically compared. Then the roles of PAA in biomimetic collagen IM within one-analog and two-analog systems are discussed, respectively. Moreover, mineralization of some self-mineralizable collagen matrices is described. Due to the interactions between collagen and PAA play a crucial role in the processes of collagen mineralization, some reference researches are also provided involving the collagen/PAA interactions in some other fields. Finally, this review is ended with an outlook for future potential improvements based on the collection of existing bottlenecks in this field.

collagen hydroxyapatite mineralization polyacrylic acid tissue engineering

SCI ; EI

英语

第一 ; 通讯

Innovation/Entrepreneurship Program of Jiangsu Province[[2020] 30822] ; Science Foundation of National Key Laboratory of Science and Technology on Advanced Composites in Special Environments[JCKYS2021603C014]

Polymer Science

Polymer Science

WOS:000939445700001

WILEY-V C H VERLAG GMBH

20231013674794

Biodegradation ; Biomimetic processes ; Carboxylic acids ; Histology ; Hydroxyapatite ; Mineralogy ; Tissue ; Tissue engineering

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biotechnology:461.8 ; Mineralogy:482 ; Biochemistry:801.2 ; Organic Compounds:804.1 ; Inorganic Compounds:804.2

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
2.Jiangnan Univ, Coll Text Sci & Engn, Key Lab Ecotext, Minist Educ, Wuxi 214122, Peoples R China

Chen, Lei,Zeng, Zhiyong,Li, Wenbing. Poly(acrylic acid)-Assisted Intrafibrillar Mineralization of Type I Collagen: A Review[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2023,44(9).

Chen, Lei,Zeng, Zhiyong,&Li, Wenbing.(2023).Poly(acrylic acid)-Assisted Intrafibrillar Mineralization of Type I Collagen: A Review.MACROMOLECULAR RAPID COMMUNICATIONS,44(9).

Chen, Lei,et al."Poly(acrylic acid)-Assisted Intrafibrillar Mineralization of Type I Collagen: A Review".MACROMOLECULAR RAPID COMMUNICATIONS 44.9(2023).