南方科技大学知识苑(SUSTech KC): Additional mutations based on Omicron BA.2.75 mediate its further evasion from broadly neutralizing antibodies

题名	Additional mutations based on Omicron BA.2.75 mediate its further evasion from broadly neutralizing antibodies
作者	Guo，Huimin 1; Jiang，Jie1 ; Shen，Senlin1 ; Ge，Xiangyang 1; Fan，Qing1 ; Zhou，Bing1 ; Cheng，Lin 1; Ju，Bin 1,2; Zhang，Zheng 1,2,3
通讯作者	Ju，Bin
发表日期	2023-04-21
DOI	10.1016/j.isci.2023.106283
发表期刊	iScience 影响因子和分区
EISSN	2589-0042
卷号	26 期号:4
摘要	SARS-CoV-2 Omicron BA.2.75 subvariant has evolved to a series of progeny variants carrying several additional mutations in the receptor-binding domain (RBD). Here, we investigated whether and how these single mutations based on BA.2.75 affect the neutralization of currently available anti-RBD monoclonal antibodies (mAbs) with well-defined structural information. Approximately 34% of mAbs maintained effective neutralizing activities against BA.2.75, consistent with those against BA.2, BA.4/5, and BA.2.12.1. Single additional R346T, K356T, L452R, or F486S mutations further facilitated BA.2.75-related progeny variants to escape from broadly neutralizing antibodies (bnAbs) at different degree. Only LY-CoV1404 (bebtelovimab) displayed a first-class neutralization potency and breadth against all tested Omicron subvariants. Overall, these data make a clear connection between virus escape and antibody recognizing antigenic epitopes, which facilitate to develop next-generation universal bnAbs against emerging SARS-CoV-2 variants.
关键词	Immunology Virology
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Key Plan for Scientific Research and Devel- opment of China["2021YFC2301900","2021YFC0864500"] ; National Science Fund for Distinguished Young Scholars[82025022] ; National Natural Science Foundation of China["82002140","92169204","82171752"] ; Guangdong Basic and Applied Basic Research Foundation[2021B15 15020034] ; Shenzhen Science and Technology Program[RCYX20200714114700046] ; Science and Technology Innovation Committee of Shenzhen Municipality["JSGG20220226085550001","JSGG20200207155251653","JSGG20210901145200002"] ; Shenzhen Natural Science Foundation["JCYJ20190809115617365","JCYJ20220530163413031","JCYJ20200109144201725"]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000996401600001
出版者	CELL PRESS
Scopus记录号	2-s2.0-85150053607
来源库	Scopus
引用统计	被引频次[WOS]：6
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/515736
专题	南方科技大学医学院南方科技大学第二附属医院
作者单位	1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong Province,518112,China 2.Guangdong Key Laboratory for Anti-infection Drug Quality Evaluation,Shenzhen,Guangdong Province,518112,China 3.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Shenzhen,Guangdong Province,518112,China
第一作者单位	南方科技大学医学院; 南方科技大学第二附属医院
通讯作者单位	南方科技大学医学院; 南方科技大学第二附属医院
第一作者的第一单位	南方科技大学医学院; 南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Guo，Huimin,Jiang，Jie,Shen，Senlin,et al. Additional mutations based on Omicron BA.2.75 mediate its further evasion from broadly neutralizing antibodies[J]. iScience,2023,26(4).
APA	Guo，Huimin.,Jiang，Jie.,Shen，Senlin.,Ge，Xiangyang.,Fan，Qing.,...&Zhang，Zheng.(2023).Additional mutations based on Omicron BA.2.75 mediate its further evasion from broadly neutralizing antibodies.iScience,26(4).
MLA	Guo，Huimin,et al."Additional mutations based on Omicron BA.2.75 mediate its further evasion from broadly neutralizing antibodies".iScience 26.4(2023).