Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants

Ju, Bin1,2; Zhang, Qi3; Wang, Ziyi4; Aw, Zhen Qin5,6,7; Chen, Peng3; Zhou, Bing1; Wang, Ruoke3; Ge, Xiangyang1; Lv, Qining3; Cheng, Lin1; Zhang, Rui3; Wong, Yi Hao5,6,7; Chen, Huixin5,6,7; Wang, Haiyan1; Shan, Sisi3; Liao, Xuejiao1; Shi, Xuanling3; Liu, Lei1,2; Chu, Justin Jang Hann5,6,7; Wang, Xinquan4; Zhang, Zheng1,2,8; Zhang, Linqi3,9,10

2023-03-01

10.1038/s41590-023-01449-6

NATURE IMMUNOLOGY   影响因子和分区

1529-2908

1529-2916

["The omicron variants of SARS-CoV-2 have substantial ability to escape infection- and vaccine-elicited antibody immunity. Here, we investigated the extent of such escape in nine convalescent patients infected with the wild-type SARS-CoV-2 during the first wave of the pandemic. Among the total of 476 monoclonal antibodies (mAbs) isolated from peripheral memory B cells, we identified seven mAbs with broad neutralizing activity to all variants tested, including various omicron subvariants. Biochemical and structural analysis indicated the majority of these mAbs bound to the receptor-binding domain, mimicked the receptor ACE2 and were able to accommodate or inadvertently improve recognition of omicron substitutions. Passive delivery of representative antibodies protected K18-hACE2 mice from infection with omicron and beta SARS-CoV-2. A deeper understanding of how the memory B cells that produce these antibodies could be selectively boosted or recalled can augment antibody immunity against SARS-CoV-2 variants.","Zhang and colleagues perform functional, biochemical and structural analysis of a set of antibodies isolated from COVID-19 convalescents infected with wild-type SARS-CoV-2 during the first wave of the pandemic and show they have broad neutralizing activity against all SARS-CoV-2 variants tested, including omicron."]

SCI

英语

NI论文

通讯

National Natural Science Foundation["82171752","32171202","2021YFC0864500","2022YFC2604103","2022YFC2303403","2022YFF1203100","2021YFC2300104"] ; null[92169205] ; null[82150205] ; null[32270983] ; null[92169204] ; null[82002140] ; null[20221080056] ; null[82025022] ; null[2021B1515020034] ; null[2019A1515011197] ; null[RCYX20200714114700046] ; null[JSGG20220226085550001] ; null[JSGG20200207155251653] ; null[JSGG20210901145200002] ; null[JCYJ20190809115617365] ; null[JCYJ20200109144201725] ; null[CGAug16M009] ; null[NUHSRO/2020/066/NUSMedCovid/01/BSL3] ; null[NUHSRO/2020/050/RO5+5/NUHS-COVID/4] ; null[MOE2017-T2-2-014] ; null[MOH-COVID19RF2-0001]

Immunology

Immunology

WOS:000948715400002

NATURE PORTFOLIO

IMMUNOLOGY

Web of Science

1.Shenzhen Third Peoples Hosp, Inst Hepatol, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen, Peoples R China
3.Tsinghua Univ, Sch Med, Ctr Global Hlth & Infect Dis, Comprehens AIDS Res Ctr,Dept Basic Med Sci, Beijing, Peoples R China
4.Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Beijing Frontier Res Ctr Biol Struct, Collaborat Innovat Ctr Biotherapy,Minist Educ,Key, Beijing, Peoples R China
5.Natl Univ Singapore, Yong Loo Lin Sch Med, Biosafety Level Core Facil 3, Singapore, Singapore
6.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Lab Mol RNA Virol & Antiviral Strategies, Singapore, Singapore
7.Natl Univ Singapore, Yong Loo Lin Sch Med, Infect Dis Translat Res Programme, Singapore, Singapore
8.Guangdong Key Lab Antiinfect Drug Qual Evaluat, Shenzhen, Peoples R China
9.Tsinghua Univ, Inst Biopharmaceut & Hlth Engn, Tsinghua Shenzhen Int Grad Sch, Shenzhen, Peoples R China
10.Inst Biomed Hlth Technol & Engn, Shenzhen Bay Lab, Shenzhen, Peoples R China

Ju, Bin,Zhang, Qi,Wang, Ziyi,et al. Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants[J]. NATURE IMMUNOLOGY,2023,24(4).

Ju, Bin.,Zhang, Qi.,Wang, Ziyi.,Aw, Zhen Qin.,Chen, Peng.,...&Zhang, Linqi.(2023).Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants.NATURE IMMUNOLOGY,24(4).

Ju, Bin,et al."Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants".NATURE IMMUNOLOGY 24.4(2023).