南方科技大学知识苑(SUSTech KC): Pharmacokinetics of Antituberculosis Drugs in Plasma and Cerebrospinal Fluid in a Patient with Pre-Extensive Drug Resistant Tuberculosis Meningitis

题名	Pharmacokinetics of Antituberculosis Drugs in Plasma and Cerebrospinal Fluid in a Patient with Pre-Extensive Drug Resistant Tuberculosis Meningitis
作者	Liang, Zhilin 1; Liao, Weiming 2; Chen, Qifu 3; Li, Hui 1 ; Ye, Meiling 1; Zou, Jin 4; Deng, Guofang 1; Zhang, Peize 1
通讯作者	Zhang, Peize
发表日期	2023
DOI	10.2147/IDR.S401281
发表期刊	INFECTION AND DRUG RESISTANCE 影响因子和分区
ISSN	1178-6973
卷号	16
摘要	Drug-resistant tuberculous meningitis (TBM) is the most devastating and critical form of extrapulmonary tuberculosis. Here, we present a case of a 45-year-old male with pre-extensive drug-resistant tuberculosis meningitis (pre-XDR-TBM). He underwent emergency surgery for the long-tunneled external ventricular drainage (LTEVD). Molecular test and phenotypic drug sensitivity test (DST) of Mycobacterium tuberculosis in cerebrospinal fluid (CSF) showed that the isolate was resistant to both rifampin and fluoroquinolones. An anti-tuberculous regimen of isoniazid, pyrazinamide, cycloserine, moxifloxacin, clofazimine, and linezolid was tailored accordingly. We monitored the drug concentration in his plasma and CSF before (at 0-hour) and after anti-TB drugs administration (at 1-hour, 2-hour, 6-hour, and 12-hour) on 10th day after treatment initiation. We hope to provide reference values of drug exposures in plasma and CSF for patients with pre-XDR-TBM.
关键词	pre-extensive drug resistant TB tuberculous meningitis pharmacokinetics long-tunneled external ventricular drain drug concentration
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Summit Plan for Foshan High level Hospital Construction[FSSYKF-2020001] ; Guangdong Provincial Clinical Research Center for Tuberculosis Project[2020B1111170014] ; Project of Shenzhen Third People's Hospital["G2021023","G2021022"]
WOS研究方向	Infectious Diseases ; Pharmacology & Pharmacy
WOS类目	Infectious Diseases ; Pharmacology & Pharmacy
WOS记录号	WOS:000957950700001
出版者	DOVE MEDICAL PRESS LTD
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/523991
专题	南方科技大学第二附属医院
作者单位	1.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Dept Pulm Med & TB, Shenzhen, Peoples R China 2.Jiangxi Prov Canc Hosp, Dept Thorac Oncol, Nanchang, Peoples R China 3.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Dept Neurosurg, Shenzhen, Peoples R China 4.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Dept Clin Lab, Shenzhen, Peoples R China
第一作者单位	南方科技大学第二附属医院
通讯作者单位	南方科技大学第二附属医院
第一作者的第一单位	南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Liang, Zhilin,Liao, Weiming,Chen, Qifu,et al. Pharmacokinetics of Antituberculosis Drugs in Plasma and Cerebrospinal Fluid in a Patient with Pre-Extensive Drug Resistant Tuberculosis Meningitis[J]. INFECTION AND DRUG RESISTANCE,2023,16.
APA	Liang, Zhilin.,Liao, Weiming.,Chen, Qifu.,Li, Hui.,Ye, Meiling.,...&Zhang, Peize.(2023).Pharmacokinetics of Antituberculosis Drugs in Plasma and Cerebrospinal Fluid in a Patient with Pre-Extensive Drug Resistant Tuberculosis Meningitis.INFECTION AND DRUG RESISTANCE,16.
MLA	Liang, Zhilin,et al."Pharmacokinetics of Antituberculosis Drugs in Plasma and Cerebrospinal Fluid in a Patient with Pre-Extensive Drug Resistant Tuberculosis Meningitis".INFECTION AND DRUG RESISTANCE 16(2023).