南方科技大学知识苑(SUSTech KC): Multi-Targeted Peptide-Modified Gold Nanoclusters for Treating Solid Tumors in the Liver

题名	Multi-Targeted Peptide-Modified Gold Nanoclusters for Treating Solid Tumors in the Liver
作者	Xiao, Feng1 ; Chen, Yao1 ; Qi, Jie 1; Yao, Qiaofeng 2; Xie, Jianping 2; Jiang, Xingyu1
通讯作者	Xie, Jianping; Jiang, Xingyu
发表日期	2023-03-01
DOI	10.1002/adma.202210412
发表期刊	ADVANCED MATERIALS 影响因子和分区
ISSN	0935-9648
EISSN	1521-4095
卷号	35 期号:20
摘要	Apoptosis and autophagy determine the fate of cancer cells. However, simply promoting apoptosis of tumor cells is limited in the treatment of unresectable solid liver tumors. Generally, autophagy is considered the anti-apoptotic "guardian". But the pro-apoptotic effects of autophagy can be activated by excessive endoplasmic reticulum (ER) stress. Here, amphiphilic peptide-modified glutathione (GSH)-gold nanocluster aggregates (AP(1)P(2)-PEG NCs) were designed with the enrichment of solid liver tumors and the prolonged stress in the ER, which can achieve the mutual promotion of autophagy and apoptosis in liver tumor cells. In this study, orthotopic and subcutaneous liver tumor models show the anti-tumor effectiveness of AP(1)P(2)-PEG NCs, with a better antitumor effect than sorafenib, biosafety (Lethal Dose, 50% (LD50) of 827.3 mg kg(-1)), wide therapeutic window (non-toxic in 20 times of therapeutic concentration) and high stability (blood half-life of 4 h). These findings identify an effective strategy to develop peptide-modified gold nanocluster aggregates with low toxicity, high potency, and selectivity for solid liver tumors treatment.
关键词	apoptosis autophagy endoplasmic reticulum stress gold nanoclusters liver cancer
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
重要成果	NI论文
学校署名	第一 ; 通讯
资助项目	National Key R&D Program of China["2018YFA0902600","2020YFA0908900","2021YFF1200800","2021YFF1200103","2022YFB3804"] ; National Natural Science Foundation of China[22234004] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000961643500001
出版者	WILEY-V C H VERLAG GMBH
EI入藏号	20231513875557
EI主题词	Aggregates ; Cancer cells ; Diseases ; Gold ; Nanoclusters ; Peptides ; Tumors
EI分类号	Highway Engineering:406 ; Concrete Reinforcements:412.2 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9 ; Precious Metals:547.1 ; Nanotechnology:761 ; Solid State Physics:933
ESI学科分类	MATERIALS SCIENCE
来源库	Web of Science
引用统计	被引频次[WOS]：34
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/523997
专题	工学院_生物医学工程系
作者单位	1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Guangdong, Peoples R China 2.Natl Univ Singapore, Dept Chem & Biomol Engn, Kent Ridge, Singapore 117585, Singapore
第一作者单位	生物医学工程系
通讯作者单位	生物医学工程系
第一作者的第一单位	生物医学工程系
推荐引用方式 GB/T 7714	Xiao, Feng,Chen, Yao,Qi, Jie,et al. Multi-Targeted Peptide-Modified Gold Nanoclusters for Treating Solid Tumors in the Liver[J]. ADVANCED MATERIALS,2023,35(20).
APA	Xiao, Feng,Chen, Yao,Qi, Jie,Yao, Qiaofeng,Xie, Jianping,&Jiang, Xingyu.(2023).Multi-Targeted Peptide-Modified Gold Nanoclusters for Treating Solid Tumors in the Liver.ADVANCED MATERIALS,35(20).
MLA	Xiao, Feng,et al."Multi-Targeted Peptide-Modified Gold Nanoclusters for Treating Solid Tumors in the Liver".ADVANCED MATERIALS 35.20(2023).