Feasibility and usability of a digital health technology system to monitor mobility and assess medication adherence in mild-to-moderate Parkinson's disease

Debelle, Heloise1; Packer, Emma1; Beales, Esther2; Bailey, Harry G. B.1; Mc Ardle, Riona1,3,4; Brown, Philip5; Hunter, Heather5; Ciravegna, Fabio6,7; Ireson, Neil6; Evers, Jordi8; Niessen, Martijn8; Shi, Jian Qing9; Yarnall, Alison J.1,3,4,5; Rochester, Lynn1,3,4,5; Alcock, Lisa1,3,4; Del Din, Silvia1,3,4

2023-03-15

10.3389/fneur.2023.1111260

FRONTIERS IN NEUROLOGY   影响因子和分区

1664-2295

IntroductionParkinson's disease (PD) is a neurodegenerative disorder which requires complex medication regimens to mitigate motor symptoms. The use of digital health technology systems (DHTSs) to collect mobility and medication data provides an opportunity to objectively quantify the effect of medication on motor performance during day-to-day activities. This insight could inform clinical decision-making, personalise care, and aid self-management. This study investigates the feasibility and usability of a multi-component DHTS to remotely assess self-reported medication adherence and monitor mobility in people with Parkinson's (PwP). MethodsThirty participants with PD [Hoehn and Yahr stage I (n = 1) and II (n = 29)] were recruited for this cross-sectional study. Participants were required to wear, and where appropriate, interact with a DHTS (smartwatch, inertial measurement unit, and smartphone) for seven consecutive days to assess medication adherence and monitor digital mobility outcomes and contextual factors. Participants reported their daily motor complications [motor fluctuations and dyskinesias (i.e., involuntary movements)] in a diary. Following the monitoring period, participants completed a questionnaire to gauge the usability of the DHTS. Feasibility was assessed through the percentage of data collected, and usability through analysis of qualitative questionnaire feedback. ResultsAdherence to each device exceeded 70% and ranged from 73 to 97%. Overall, the DHTS was well tolerated with 17/30 participants giving a score > 75% [average score for these participants = 89%, from 0 (worst) to 100 (best)] for its usability. Usability of the DHTS was significantly associated with age (rho = -0.560, BCa 95% CI [-0.791, -0.207]). This study identified means to improve usability of the DHTS by addressing technical and design issues of the smartwatch. Feasibility, usability and acceptability were identified as key themes from PwP qualitative feedback on the DHTS. ConclusionThis study highlighted the feasibility and usability of our integrated DHTS to remotely assess medication adherence and monitor mobility in people with mild-to-moderate Parkinson's disease. Further work is necessary to determine whether this DHTS can be implemented for clinical decision-making to optimise management of PwP.

Parkinson's disease medication adherence smartwatch wearable technology remote monitoring mobility inertial measurement units motor complications

SCI

英语

其他

Neurosciences & Neurology

Clinical Neurology ; Neurosciences

WOS:000956585900001

FRONTIERS MEDIA SA

Web of Science

1.Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Newcastle Upon Tyne, England
2.Newcastle Univ, Fac Med Sci, Newcastle Upon Tyne, England
3.Newcastle Tyne Hosp NHS Fdn Trust, Natl Inst Hlth & Care Res NIHR, Newcastle Biomed Res Ctr BRC, Newcastle Upon Tyne, England
4.Newcastle Univ, Newcastle Upon Tyne, England
5.Newcastle Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, England
6.Univ Sheffield, INSIGNEO Inst Silico Med, Dept Comp Sci, Sheffield, England
7.Univ Torino, Dipartimento Informat, Turin, Italy
8.McRoberts BV, The Hague, Netherlands
9.Southern Univ Sci & Technol, Dept Stat & Data Sci, Shenzhen, Peoples R China

Debelle, Heloise,Packer, Emma,Beales, Esther,et al. Feasibility and usability of a digital health technology system to monitor mobility and assess medication adherence in mild-to-moderate Parkinson's disease[J]. FRONTIERS IN NEUROLOGY,2023,14.

Debelle, Heloise.,Packer, Emma.,Beales, Esther.,Bailey, Harry G. B..,Mc Ardle, Riona.,...&Del Din, Silvia.(2023).Feasibility and usability of a digital health technology system to monitor mobility and assess medication adherence in mild-to-moderate Parkinson's disease.FRONTIERS IN NEUROLOGY,14.

Debelle, Heloise,et al."Feasibility and usability of a digital health technology system to monitor mobility and assess medication adherence in mild-to-moderate Parkinson's disease".FRONTIERS IN NEUROLOGY 14(2023).