Epitranscriptomics in the development, functions, and disorders of cancer stem cells

Hao, Linlin1; Zhang, Jian2; Liu, Zhongshan1; Lin, Xia1; Guo, Jie1

2023-03-17

10.3389/fonc.2023.1145766

FRONTIERS IN ONCOLOGY   影响因子和分区

2234-943X

Biomolecular modifications play an important role in the development of life, and previous studies have investigated the role of DNA and proteins. In the last decade, with the development of sequencing technology, the veil of epitranscriptomics has been gradually lifted. Transcriptomics focuses on RNA modifications that affect gene expression at the transcriptional level. With further research, scientists have found that changes in RNA modification proteins are closely linked to cancer tumorigenesis, progression, metastasis, and drug resistance. Cancer stem cells (CSCs) are considered powerful drivers of tumorigenesis and key factors for therapeutic resistance. In this article, we focus on describing RNA modifications associated with CSCs and summarize the associated research progress. The aim of this review is to identify new directions for cancer diagnosis and targeted therapy.

epitranscriptomics RNA modification cancer stem cell stemness RNA-modifying enzyme

SCI

英语

其他

Oncology

Oncology

WOS:000961284900001

FRONTIERS MEDIA SA

Web of Science

1.Second Hosp Jilin Univ, Dept Tumor Radiotherapy, Changchun, Peoples R China
2.Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen, Peoples R China

Hao, Linlin,Zhang, Jian,Liu, Zhongshan,et al. Epitranscriptomics in the development, functions, and disorders of cancer stem cells[J]. FRONTIERS IN ONCOLOGY,2023,13.

Hao, Linlin,Zhang, Jian,Liu, Zhongshan,Lin, Xia,&Guo, Jie.(2023).Epitranscriptomics in the development, functions, and disorders of cancer stem cells.FRONTIERS IN ONCOLOGY,13.

Hao, Linlin,et al."Epitranscriptomics in the development, functions, and disorders of cancer stem cells".FRONTIERS IN ONCOLOGY 13(2023).