Association between glycolipids and risk of obstructive sleep apnea: A population-based study

Zheng, Murui1; Duan, Xueru2,3; Zhou, Huanning4; Sun, Weidi5; Sun, Guoqiang6; Chen, Jianying6; Wu, Xiuyi7; Rong, Sijing8; Huang, Jun9; Zhao, Wengjing10; Deng, Hai11; Liu, Xudong3

2023-03-16

10.3389/fnut.2023.974801

FRONTIERS IN NUTRITION   影响因子和分区

2296-861X

BackgroundThis study aimed to investigate the associations between multiple glycolipid biomarkers and the risk of obstructive sleep apnea (OSA). MethodsParticipants (10,286) aged from 35 to 74 years old were included in this cross-sectional study from the baseline survey of the Guangzhou Heart Study. OSA was ascertained using both Berlin Questionnaire and STOP-BANG Questionnaire. Fasting blood samples were collected from each participant; fasting blood glucose (FBG) and serum concentrations of high-density lipoprotein cholesterol (HDL-CH), low-density lipoprotein cholesterol (LDL-CH), total cholesterol (TC), and triglyceride (TG) were determined. Odds ratio (OR) with 95% confidence interval (CI) was calculated using the multivariate logistic regression model after adjustment for covariates. ResultsOf the participants included, 15.56% were categorized into the pre-OSA group, and 8.22% into the OSA group. When comparing the highest with the lowest quartiles, HDL-HC was associated with a 22% (OR: 0.78, 95% CI: 0.65-0.94) and 41% (OR: 0.59, 95% CI: 0.45-0.78) reduced risk of pre-OSA and OSA, triglyceride was associated with a 32% (OR 1.32, 95% CI 1.08-1.60) and a 56% (OR 1.56, 95% CI 1.18-2.07) increased risk of pre-OSA and OSA, and FBG was associated with a 1.37-fold (95% CI 1.13-1.67) risk of pre-OSA and 1.38-fold (95% CI 1.03-1.85) risk of OSA. A significant exposure-response trend was observed for HDL-HC, TG, and FBG with both OSA and Pre-OSA (all p < 0.05). No significant association of LDL-CH and TC with the risk of both pre-OSA and OSA was observed. ConclusionThe findings suggest that serum HDL-CH was inversely associated with OSA risk, while elevated serum TG and FBG could increase the risk of OSA. Healthy glycolipid metabolism warrants more attention in the field of OSA prevention.

lipid blood glucose obstructive sleep apnea risk factor biomarker

SCI

英语

通讯

Guangdong Basic and Applied Basic Research Foundation[2022A1515010686] ; Medical Science and Technology Research Foundation of Guangdong Province[A2023408] ; Guangdong Provincial Key RD Program[2019B020230004] ; National Key R&D Program of China[2018YFC1312502]

Nutrition & Dietetics

Nutrition & Dietetics

WOS:000961520800001

FRONTIERS MEDIA SA

Web of Science

1.Guangzhou Ctr Dis Control & Prevent, Dept Community Hlth, Guangzhou, Peoples R China
2.Sun Yat sen Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Peoples R China
3.Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou, Peoples R China
4.Guangzhou Yuexiu Dist Ctr Dis Control & Prevent, Guangzhou, Peoples R China
5.Zhejiang Univ, Womens Hosp, Sch Med, Sch Publ Hlth, Hangzhou, Peoples R China
6.Baiyun St Community Hlth Serv Ctr, Guangzhou, Peoples R China
7.Nancun Town Community Hlth Serv Ctr, Guangzhou, Peoples R China
8.Guangzhou Haizhu Dist Ctr Dis Control & Prevent, Guangzhou, Peoples R China
9.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Inst Geriatr, Dept Geriatr, Guangzhou, Peoples R China
10.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China
11.Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Guangdong Prov Peoples Hosp, Dept Cardiol, Guangzhou, Peoples R China

Zheng, Murui,Duan, Xueru,Zhou, Huanning,et al. Association between glycolipids and risk of obstructive sleep apnea: A population-based study[J]. FRONTIERS IN NUTRITION,2023,10.

Zheng, Murui.,Duan, Xueru.,Zhou, Huanning.,Sun, Weidi.,Sun, Guoqiang.,...&Liu, Xudong.(2023).Association between glycolipids and risk of obstructive sleep apnea: A population-based study.FRONTIERS IN NUTRITION,10.

Zheng, Murui,et al."Association between glycolipids and risk of obstructive sleep apnea: A population-based study".FRONTIERS IN NUTRITION 10(2023).