Making small molecules in plants: A chassis for synthetic biology-based production of plant natural products

Liu，Xinyu1; Zhang，Peijun1; Zhao，Qiao2; Huang，Ancheng C.1

2023-02-01

10.1111/jipb.13330

Journal of Integrative Plant Biology   影响因子和分区

1672-9072

1744-7909

Plant natural products have been extensively exploited in food, medicine, flavor, cosmetic, renewable fuel, and other industrial sectors. Synthetic biology has recently emerged as a promising means for the cost-effective and sustainable production of natural products. Compared with engineering microbes for the production of plant natural products, the potential of plants as chassis for producing these compounds is underestimated, largely due to challenges encountered in engineering plants. Knowledge in plant engineering is instrumental for enabling the effective and efficient production of valuable phytochemicals in plants, and also paves the way for a more sustainable future agriculture. In this manuscript, we briefly recap the biosynthesis of plant natural products, focusing primarily on industrially important terpenoids, alkaloids, and phenylpropanoids. We further summarize the plant hosts and strategies that have been used to engineer the production of natural products. The challenges and opportunities of using plant synthetic biology to achieve rapid and scalable production of high-value plant natural products are also discussed.

biosynthesis natural products plant engineering synthetic biology

SCI

英语

第一 ; 通讯

null[32061143023] ; null[2019KSYS006]

Biochemistry & Molecular Biology ; Plant Sciences

Biochemistry & Molecular Biology ; Plant Sciences

WOS:000905247200001

WILEY

2-s2.0-85138576677

Scopus

1.Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes,Department of Biology,School of Life Sciences,SUSTech-PKU Institute of Plant and Food Science,Southern University of Science and Technology,Shenzhen,518055,China
2.Shenzhen Institutes of Advanced Technology (SIAT),the Chinese Academy of Sciences,Shenzhen,518055,China

Liu，Xinyu,Zhang，Peijun,Zhao，Qiao,et al. Making small molecules in plants: A chassis for synthetic biology-based production of plant natural products[J]. Journal of Integrative Plant Biology,2023,65(2):417-443.

Liu，Xinyu,Zhang，Peijun,Zhao，Qiao,&Huang，Ancheng C..(2023).Making small molecules in plants: A chassis for synthetic biology-based production of plant natural products.Journal of Integrative Plant Biology,65(2),417-443.

Liu，Xinyu,et al."Making small molecules in plants: A chassis for synthetic biology-based production of plant natural products".Journal of Integrative Plant Biology 65.2(2023):417-443.