南方科技大学知识苑(SUSTech KC): Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly

题名	Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly
作者	Zhao，Zhennan 1; Huang，Youhua 2; Liu，Congcong 3,4; Zhu，Dongjie 5,6; Gao，Shuaixin 7,8; Liu，Sheng3 ; Peng，Ruchao 1,9; Zhang，Ya 2; Huang，Xiaohong 2; Qi，Jianxun 1,10,11; Wong，Catherine C.L.12; Zhang，Xinzheng 6,10; Wang，Peiyi3 ; Qin，Qiwei 2; Gao，George F.1,10
通讯作者	Qi，Jianxun; Wong，Catherine C.L.; Zhang，Xinzheng; Wang，Peiyi; Qin，Qiwei; Gao，George F.
共同第一作者	Zhao，Zhennan; Huang，Youhua; Liu，Congcong; Zhu，Dongjie; Gao，Shuaixin
发表日期	2023-04-12
DOI	10.1038/s41467-023-37681-9
发表期刊	Nature communications 影响因子和分区
EISSN	2041-1723
卷号	14 期号:1
摘要	Singapore grouper iridovirus (SGIV), one of the nucleocytoviricota viruses (NCVs), is a highly pathogenic iridovirid. SGIV infection results in massive economic losses to the aquaculture industry and significantly threatens global biodiversity. In recent years, high morbidity and mortality in aquatic animals have been caused by iridovirid infections worldwide. Effective control and prevention strategies are urgently needed. Here, we present a near-atomic architecture of the SGIV capsid and identify eight types of capsid proteins. The viral inner membrane-integrated anchor protein colocalizes with the endoplasmic reticulum (ER), supporting the hypothesis that the biogenesis of the inner membrane is associated with the ER. Additionally, immunofluorescence assays indicate minor capsid proteins (mCPs) could form various building blocks with major capsid proteins (MCPs) before the formation of a viral factory (VF). These results expand our understanding of the capsid assembly of NCVs and provide more targets for vaccine and drug design to fight iridovirid infections.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
重要成果	NI论文
学校署名	共同第一 ; 通讯
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29010202] ; National Natural Science Foundation of China["32150005","CARS-47-G16"] ; Medical and Scientific Innovation Project of the Chinese Academy of Medical Science[31930115] ; null[2022-12M-1-004]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000968041600001
出版者	NATURE PORTFOLIO
Scopus记录号	2-s2.0-85152275730
来源库	Scopus
引用统计	被引频次[WOS]：13
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/524492
专题	生命科学学院_生物系生命科学学院冷冻电镜中心
作者单位	1.CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,100101,China 2.College of Marine Sciences,South China Agricultural University,Guangdong Laboratory for Lingnan Modern Agriculture,Guangzhou,510642,China 3.Cryo-EM Center,Department of Biology,Southern University of Science and Technology,Shenzhen,518055,China 4.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,Shenzhen,518112,China 5.School of Life Science,University of Science and Technology of China,Hefei,230026,China 6.National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,100101,China 7.Clinical Research Institute,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science & Peking Union Medical College,100730,China 8.Ohio State University,Columbus,Department of Human Sciences & James Comprehensive Cancer Center,43210,United States 9.Perelman School of Medicine,University of Pennsylvania,Philadelphia,19104,United States 10.University of Chinese Academy of Sciences,100049,China 11.Beijing Life Science Academy,102209,China 12.Clinical Research Institute,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science & Peking Union Medical College,100730,China
通讯作者单位	生物系; 生命科学学院
推荐引用方式 GB/T 7714	Zhao，Zhennan,Huang，Youhua,Liu，Congcong,et al. Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly[J]. Nature communications,2023,14(1).
APA	Zhao，Zhennan.,Huang，Youhua.,Liu，Congcong.,Zhu，Dongjie.,Gao，Shuaixin.,...&Gao，George F..(2023).Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly.Nature communications,14(1).
MLA	Zhao，Zhennan,et al."Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly".Nature communications 14.1(2023).