南方科技大学知识苑(SUSTech KC): Distinct chromatin signatures in the Arabidopsis male gametophyte

题名	Distinct chromatin signatures in the Arabidopsis male gametophyte
作者	Danling,Zhu1 ; Yi,Wen2 ; Wanyue,Yao1 ; Haiyan,Zheng 3; Sixian,Zhou1 ; Qiqi,Zhang1 ; Li-Jia,Qu 4; Xi,Chen1 ; Zhe,Wu1
通讯作者	Xi,Chen; Zhe,Wu
共同第一作者	Danling,Zhu; Yi,Wen
发表日期	2023-03-01
DOI	10.1038/s41588-023-01329-7
发表期刊	NATURE GENETICS 影响因子和分区
ISSN	1061-4036
EISSN	1546-1718
摘要	Epigenetic reprogramming in the germline contributes to the erasure of epigenetic inheritance across generations in mammals but remains poorly characterized in plants. Here we profiled histone modifications throughout Arabidopsis male germline development. We find that the sperm cell has widespread apparent chromatin bivalency, which is established by the acquisition of H3K27me3 or H3K4me3 at pre-existing H3K4me3 or H3K27me3 regions, respectively. These bivalent domains are associated with a distinct transcriptional status. Somatic H3K27me3 is generally reduced in sperm, while dramatic loss of H3K27me3 is observed at only similar to 700 developmental genes. The incorporation of the histone variant H3.10 facilitates the establishment of sperm chromatin identity without a strong impact on resetting of somatic H3K27me3. Vegetative nuclei harbor thousands of specific H3K27me3 domains at repressed genes, while pollination-related genes are highly expressed and marked by gene body H3K4me3. Our work highlights putative chromatin bivalency and restricted resetting of H3K27me3 at developmental regulators as key features in plant pluripotent sperm.
相关链接	[来源记录]
收录类别	SCI
语种	英语
重要成果	NI论文
学校署名	第一 ; 共同第一 ; 通讯
资助项目	National Natural Science Foundation of China["32270369","31970277","32170348","2022A1515010505"] ; null[32070645] ; null[2016ZT06S172] ; null[JCYJ20210324104803009] ; null[JCYJ20190809141201671] ; null[20200925153455004] ; null[KYTDPT20181011104005] ; null[ZDSYS20200811144002008] ; null[2019KSYS006]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000971784400004
出版者	NATURE PORTFOLIO
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
来源库	Web of Science
引用统计	被引频次[WOS]：21
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/527482
专题	南方科技大学-北京大学植物与食品联合研究所生命科学学院生命科学学院_生物系
作者单位	1.Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China. 2.Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China 3.Center for Advanced Biotechnology and Medicine, Biological Mass Spectrometry Facility, Rutgers University, Piscataway, NJ, USA 4.State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing, China
第一作者单位	南方科技大学-北京大学植物与食品联合研究所; 生物系; 生命科学学院
通讯作者单位	南方科技大学-北京大学植物与食品联合研究所; 生物系; 生命科学学院
第一作者的第一单位	南方科技大学-北京大学植物与食品联合研究所; 生物系; 生命科学学院
推荐引用方式 GB/T 7714	Danling,Zhu,Yi,Wen,Wanyue,Yao,et al. Distinct chromatin signatures in the Arabidopsis male gametophyte[J]. NATURE GENETICS,2023.
APA	Danling,Zhu.,Yi,Wen.,Wanyue,Yao.,Haiyan,Zheng.,Sixian,Zhou.,...&Zhe,Wu.(2023).Distinct chromatin signatures in the Arabidopsis male gametophyte.NATURE GENETICS.
MLA	Danling,Zhu,et al."Distinct chromatin signatures in the Arabidopsis male gametophyte".NATURE GENETICS (2023).