Green synthesis of mesoporous and biodegradable iron silicide nanoparticles for photothermal cancer therapy

Guo, Xutao1,2,3; Wang, Shuxian4; Wang, Shubin1,2; Wang, Jun4; Jiang, Feng1,2; Liu, Yuhan1,2; Storey, Catherine J.3; Theis, Wolfgang3; Lu, Zhouguang1,2; Li, Kai4; Canham, Leigh T.3; Xu, Zhenghe1,2

2023-03-01

10.1039/d2tb02399g

JOURNAL OF MATERIALS CHEMISTRY B   影响因子和分区

2050-750X

2050-7518

Photothermal nanomaterials have shown great potential for photothermal therapy. In this study, we developed a simple green method of magnesiothermic co-reduction for the synthesis of mesoporous, magnetic and biodegradable iron silicide nanoparticles (FeSi NPs) as applied to photothermal therapy (PTT). Starting from biogenic tabasheer extracted from bamboo and Fe2O3, the resultant FeSi NPs with a much lower band gap exhibited excellent optical absorption with a photothermal conversion efficiency of 76.2%, indicating a good photothermal performance. The weight extinction coefficient was measured to be 13.3 L g(-1) cm(-1) at 1064 nm (second near-infrared window, NIR-II), which surpassed the performance of other competitive Si-based and Fe-based photothermal agents. Results of the cell viability assay showed that cells could be killed by NIR-II laser irradiation with the synthesized FeSi NPs. In vivo results on mice showed clearly an efficient suppression of tumour growth by photothermal treatment with FeSi NPs. FeSi NPs were found to be biodegradable in simulated body fluids. The results from our work indicate that FeSi NPs are a new class of promising photothermal agents (PTAs) for application in cancer therapy.

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China["51974162","21938003","22008105"] ; Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials[ZDSYS20200421111401738]

Materials Science

Materials Science, Biomaterials

WOS:000972834900001

ROYAL SOC CHEMISTRY

20231714021060

Body fluids ; Conversion efficiency ; Diseases ; Energy gap ; Infrared devices ; Iron ; Mammals ; Nanomagnetics ; Nanoparticles ; Silicides ; Silicon ; Synthesis (chemical)

Biological Materials and Tissue Engineering:461.2 ; Energy Conversion Issues:525.5 ; Iron:545.1 ; Nonferrous Metals and Alloys excluding Alkali and Alkaline Earth Metals:549.3 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Light/Optics:741.1 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Chemical Products Generally:804 ; Solid State Physics:933

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen Key Lab Interfacial Sci & Engn Mat, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Key Univ Lab Highly Efficient Utilizat Solar Energ, Shenzhen 518055, Peoples R China
3.Univ Birmingham, Sch Phys & Astron, Nanoscale Phys Res Lab, Edgbaston, Birmingham B15 2TT, England
4.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China

Guo, Xutao,Wang, Shuxian,Wang, Shubin,et al. Green synthesis of mesoporous and biodegradable iron silicide nanoparticles for photothermal cancer therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2023,11(18):4065-4075.

Guo, Xutao.,Wang, Shuxian.,Wang, Shubin.,Wang, Jun.,Jiang, Feng.,...&Xu, Zhenghe.(2023).Green synthesis of mesoporous and biodegradable iron silicide nanoparticles for photothermal cancer therapy.JOURNAL OF MATERIALS CHEMISTRY B,11(18),4065-4075.

Guo, Xutao,et al."Green synthesis of mesoporous and biodegradable iron silicide nanoparticles for photothermal cancer therapy".JOURNAL OF MATERIALS CHEMISTRY B 11.18(2023):4065-4075.