Comparative genomics revealed that Vibrio furnissii and Vibrio fluvialis have mutations in genes related to T6SS1 and T6SS2

Sun, Jiakai1; Su, Haochen1; Zhang, Wenhui2,3; Luo, Xuesong4; Li, Ruichao2,3; Liu, Ming5

2023-05-01

10.1007/s00203-023-03557-1

ARCHIVES OF MICROBIOLOGY   影响因子和分区

0302-8933

1432-072X

The type VI secretion system (T6SS) is important for interbacterial competition and virulence in Vibrio species. It is generally agreed that T6SS provides a fitness advantage to Vibrios. Some Vibrio species possess one, while others possess two T6SSs. Even within the same Vibrio species, different strains can harbor a variable number of T6SSs. Such is the case in V. fluvialis, an opportunistic human pathogen, that some V. fluvialis strains do not harbor T6SS1. This study found that Amphritea, Marinomonas, Marinobacterium, Vibrio, Photobacterium, and Oceanospirillum species have genes encoding V. fluvialis T6SS1 homologs. The cladogram of T6SS1 genes suggested that these genes appeared to be horizontally acquired by V. fluvialis, V. furnissii, and some other Vibrio species, when compared with the species tree. Codon insertions, codon deletions, nonsense mutations, and the insertion sequence are found in many genes, such as clpV1, tssL1, and tssF1, which encode structure components of T6SS1 in V. furnissii and V. fluvialis. Codon deletion events are more common than codon insertion, insertion sequence disruption, and nonsense mutation events in genes that encode components of T6SS1. Similarly, codon insertions and codon deletions are found in genes relevant to T6SS2, including tssM2, vgrG2 and vasH, in V. furnissii and V. fluvialis. These mutations are likely to disable the functions of T6SSs. Our findings indicate that T6SS may have a fitness disadvantage in V. furnissii and V. fluvialis, and the loss of function in T6SS may help these Vibrio species to survive under certain conditions.

Vibrio furnissii Vibrio fluvialis T6SS Mutation

SCI

英语

通讯

National College Students' innovation and entrepreneurship training program[2021102941514]

Microbiology

Microbiology

WOS:000975535800001

SPRINGER

MICROBIOLOGY

Web of Science

1.Hohai Univ, Coll Oceanog, Nanjing, Peoples R China
2.Yangzhou Univ, Coll Vet Med, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China
3.Yangzhou Univ, Inst Comparat Med, Yangzhou, Jiangsu, Peoples R China
4.Huazhong Agr Univ, Coll Resources Environm, State Key Lab Agr Microbiol, Wuhan, Peoples R China
5.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Dept Clin Lab,Hosp 2, Shenzhen 518055, Guangdong, Peoples R China

Sun, Jiakai,Su, Haochen,Zhang, Wenhui,et al. Comparative genomics revealed that Vibrio furnissii and Vibrio fluvialis have mutations in genes related to T6SS1 and T6SS2[J]. ARCHIVES OF MICROBIOLOGY,2023,205(5).

Sun, Jiakai,Su, Haochen,Zhang, Wenhui,Luo, Xuesong,Li, Ruichao,&Liu, Ming.(2023).Comparative genomics revealed that Vibrio furnissii and Vibrio fluvialis have mutations in genes related to T6SS1 and T6SS2.ARCHIVES OF MICROBIOLOGY,205(5).

Sun, Jiakai,et al."Comparative genomics revealed that Vibrio furnissii and Vibrio fluvialis have mutations in genes related to T6SS1 and T6SS2".ARCHIVES OF MICROBIOLOGY 205.5(2023).