Emerging role of bacterial outer membrane vesicle in gastrointestinal tract

Tian, Cheng-mei1,2; Yang, Mei-feng3; Xu, Hao-ming4; Zhu, Min-zheng4; Zhang, Yuan5; Yao, Jun2,6; Wang, Li-sheng2,6; Liang, Yu-jie7; Li, De-feng2,6

2023-04-27

10.1186/s13099-023-00543-2

GUT PATHOGENS   影响因子和分区

1757-4749

1757-4749

Bacteria form a highly complex ecosystem in the gastrointestinal (GI) tract. In recent years, mounting evidence has shown that bacteria can release nanoscale phospholipid bilayer particles that encapsulate nucleic acids, proteins, lipids, and other molecules. Extracellular vesicles (EVs) are secreted by microorganisms and can transport a variety of important factors, such as virulence factors, antibiotics, HGT, and defensive factors produced by host eukaryotic cells. In addition, these EVs are vital in facilitating communication between microbiota and the host. Therefore, bacterial EVs play a crucial role in maintaining the GI tract's health and proper functioning. In this review, we outlined the structure and composition of bacterial EVs. Additionally, we highlighted the critical role that bacterial EVs play in immune regulation and in maintaining the balance of the gut microbiota. To further elucidate progress in the field of intestinal research and to provide a reference for future EV studies, we also discussed the clinical and pharmacological potential of bacterial EVs, as well as the necessary efforts required to understand the mechanisms of interaction between bacterial EVs and gut pathogenesis.

Bacterial Microbiota Outer membrane vesicle Extracellular vesicles Gastrointestinal tract

SCI

英语

通讯

Gastroenterology & Hepatology ; Microbiology

Gastroenterology & Hepatology ; Microbiology

WOS:000976082900001

BMC

2-s2.0-85156267170

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Emergency, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China
3.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen, Guangdong, Peoples R China
4.South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Sch Med,Dept Gastroenterol & Hepatol, Guangzhou, Peoples R China
5.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou, Guangdong, Peoples R China
6.Jinan Univ, Shenzhen Peoples Hosp, Dept Gastroenterol, Clin Med Coll 2, 1017 Dongmen North Rd, Shenzhen 518020, Peoples R China
7.Shenzhen Kangning Hosp, Dept Child & Adolescent Psychiat, 1080 Cuizu Rd, Shenzhen 518020, Peoples R China

Tian, Cheng-mei,Yang, Mei-feng,Xu, Hao-ming,et al. Emerging role of bacterial outer membrane vesicle in gastrointestinal tract[J]. GUT PATHOGENS,2023,15(1).

Tian, Cheng-mei.,Yang, Mei-feng.,Xu, Hao-ming.,Zhu, Min-zheng.,Zhang, Yuan.,...&Li, De-feng.(2023).Emerging role of bacterial outer membrane vesicle in gastrointestinal tract.GUT PATHOGENS,15(1).

Tian, Cheng-mei,et al."Emerging role of bacterial outer membrane vesicle in gastrointestinal tract".GUT PATHOGENS 15.1(2023).