The association between daytime napping and risk of type 2 diabetes is modulated by inflammation and adiposity: Evidence from 435 342 UK-Biobank participants

Zhou, Rui1; Chen, Hao-Wen1; Huang, Yi-Ning1; Zhong, Qi1; Li, Fu-Rong1,2; Huang, Rui-Dian3; Liu, Hua-Min4; Zheng, Jia-Zhen5,6; Xu, Jia-Wen7; Wu, Xian-Bo1

2023-04-01

10.1111/1753-0407.13387

JOURNAL OF DIABETES   影响因子和分区

1753-0393

1753-0407

Background Existing evidence concerning the relationship between daytime napping and type 2 diabetes (T2D) is inconsistent, and whether the effects of napping differ by body fat percentage (BFP) and C-reactive protein (CRP) is unclear. We aimed to investigate the association between daytime napping frequency and T2D risk and whether such an association was modified by BFP and CRP.Methods We included 435 342 participants free of diabetes from the UK Biobank. Participants were categorized as nonnappers, occasional nappers, and frequent nappers based on napping frequency, and BFP/CRP was divided into quartiles. Cox proportional hazards models were used.Results During a median follow-up of 9.2 years, 17 592 T2D cases occurred. Higher frequency of daytime napping was significantly associated with an increased risk of T2D. Compared with nonnappers, the adjusted hazard ratios (HRs) for occasional nappers and habitual nappers were 1.28 (95% confidence interval [CI]: 1.24-1.32) and 1.49 (95% CI: 1.41-1.57), respectively. There was a significant additive and multiplicative interaction (relative excess risk due to interaction [RERI] = 0.490, 95% CI 0.307-0.673; p for multiplicative interaction <.001) between napping and BFP, whereby a higher hazard of T2D associated with more frequent napping was greatest among participants in the highest BFP quartile (HR = 4.45, 95% CI: 3.92-5.06). The results for CRP were similar (RERI = 0.266, 95% CI: 0.094-0.439; p for multiplicative interaction <.001).Conclusions Higher daytime napping frequency is associated with an increased T2D risk, and such relationships are modified by BFP and CRP. These findings underscore the importance of adiposity and inflammation control to mitigate diabetes risk.

adiposity cohort daytime napping inflammation type 2 diabetes

SCI

英语

其他

National Natural Science Foundation of China[82173607] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515011684] ; Open Project of the Guangdong Provincial Key Laboratory of Tropical Disease Research[2020B1212060042] ; Chinese Postdoctoral Science Foundation[2022M721463]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000969632700001

WILEY

Web of Science

1.Southern Med Univ, Sch Publ Hlth, Dept Epidemiol, Guangdong Prov Key Lab Trop Dis Res, 1063 1023 Shatai South Rd, Guangzhou 510515, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
3.Hosp Zhongluotan Town Baiyun Dist, Publ Hlth Div, Guangzhou, Peoples R China
4.Southern Med Univ, Nanfang Hosp, Dept Anesthesiol, Guangzhou, Peoples R China
5.Hong Kong Univ Sci & Technol Guangzhou, Biosci & Biomed Engn Thrust, Syst Hub, Guangzhou, Peoples R China
6.Hong Kong Univ Sci & Technol, Biosci & Biomed Engn Thrust, Syst Hub, Hong Kong, Peoples R China
7.Southern Med Univ, Sch Publ Hlth, Guangzhou, Peoples R China

Zhou, Rui,Chen, Hao-Wen,Huang, Yi-Ning,et al. The association between daytime napping and risk of type 2 diabetes is modulated by inflammation and adiposity: Evidence from 435 342 UK-Biobank participants[J]. JOURNAL OF DIABETES,2023,15(6).

Zhou, Rui.,Chen, Hao-Wen.,Huang, Yi-Ning.,Zhong, Qi.,Li, Fu-Rong.,...&Wu, Xian-Bo.(2023).The association between daytime napping and risk of type 2 diabetes is modulated by inflammation and adiposity: Evidence from 435 342 UK-Biobank participants.JOURNAL OF DIABETES,15(6).

Zhou, Rui,et al."The association between daytime napping and risk of type 2 diabetes is modulated by inflammation and adiposity: Evidence from 435 342 UK-Biobank participants".JOURNAL OF DIABETES 15.6(2023).