NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes

Wang, Yajun1,2; Nan, Jingjie1,2; Ma, Huilong3; Xu, Jiajun1; Guo, Feifei4; Wang, Yufeng4; Liang, Yongye3; Zhang, Junhu1,2; Zhu, Shoujun1,2

2023-04-01

10.1021/acs.nanolett.3c00829

NANO LETTERS   影响因子和分区

1530-6984

1530-6992

Radical lymphadenectomy remains the cornerstone of preventing tumor metastasis through the lymphatic system. Current surgical resection of lymph nodes (LNs) based on fluorescence-guided surgery (FGS) suffers from low sensitivity/ selectivity with only qualitative information, hampering accurate intraoperative decision-making. Herein, we develop a modularized theranostic system including NIR-II FGS and a sandwiched plasmonic chip (SPC). Intraoperative NIR-II FGS and detection of tumor-positive lymph nodes were performed on the gastric tumor to determine the feasibility of the modularized theranostic system in defining LN metastasis. Under the NIR-II imaging window, the orthotopic tumor and sentinel lymph nodes (SLNs) were successfully excised without ambient light interference in the operating room. Importantly, the SPC biosensor achieved 100% sensitivity and 100% specificity for tumor markers and realized rapid and high-throughput intraoperative SLN detection. We propose the synergetic design of combining the NIR-II FGS and suitable biosensor will substantially improve the efficiency of cancer diagnosis and therapy follow-up.

Modularized theranostic system Sandwiched plasmonic chip NIR-II fluorescence-guided surgery Tumor-positive lymph nodes

SCI ; EI

英语

NI论文

通讯

National Key Research and Development Program of China[2022YFC2601900] ; National Natural Science Foundation of China["21975098","22275071"] ; China Postdoctoral Science Foundation["2020TQ0119","2020M681046"]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000972699700001

AMER CHEMICAL SOC

20231814042902

Biosensors ; Decision making ; Diagnosis ; Fluorescence ; Infrared devices ; Pathology ; Plasmonics ; Surgery

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Light/Optics:741.1 ; Management:912.2 ; Plasma Physics:932.3

MATERIALS SCIENCE

Web of Science

1.Jilin Univ, First Hosp Jilin Univ, Joint Lab Optofunct Theranost Med & Chem, Changchun 130021, Peoples R China
2.Jilin Univ, Coll Chem, Ctr Supramol Chem Biol, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China
3.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
4.Jilin Univ, First Hosp Jilin Univ, Canc Inst, Changchun 130021, Peoples R China

Wang, Yajun,Nan, Jingjie,Ma, Huilong,et al. NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes[J]. NANO LETTERS,2023,23(9):4039-4048.

Wang, Yajun.,Nan, Jingjie.,Ma, Huilong.,Xu, Jiajun.,Guo, Feifei.,...&Zhu, Shoujun.(2023).NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes.NANO LETTERS,23(9),4039-4048.

Wang, Yajun,et al."NIR-II Imaging and Sandwiched Plasmonic Biosensor for Ultrasensitive Intraoperative Definition of Tumor-Invaded Lymph Nodes".NANO LETTERS 23.9(2023):4039-4048.