Prognostic biomarker CCR6 and its correlation with immune infiltration in cutaneous melanoma

Nurzat, Yeltai1; Dai, Damao2; Hu, Julong1; Zhang, Feiyu1; Lin, Zaihuan1; Huang, Yang3; Gang, Liang4; Ji, Hang4; Zhang, Xiaowen1,5,6

2023-04-25

10.3389/fonc.2023.1162406

FRONTIERS IN ONCOLOGY   影响因子和分区

2234-943X

BackgroundCutaneous melanoma (CM) is an aggressive type of skin cancer. Even after standard treatment, the recurrence and malignant progression of CM were almost inevitable. The overall survival (OS) of patients with CM varied widely, making it critical for prognostic prediction. Based on the correlation between CCR6 and melanoma incidence, we aimed to investigate the prognostic role of CCR6 and its relationship with immune infiltration in CM. MethodsWe obtained RNA sequencing data from The Cancer Genome Atlas (TCGA) to analyze the CM expression. Functional enrichment analyses, immune infiltration analyses, immune checkpoint analyses, and clinicopathology analyses were performed. Univariate and multivariate Cox regression analyses were used to identify independent prognostic factors. A nomogram model had been developed. Kaplan-Meier survival analysis and log-rank test were used to estimate the relationship between OS and CCR6 expression. ResultsCCR6 was significantly upregulated in CM. Functional enrichment analyses revealed that CCR6 was correlated with immune response. Most immune cells and immune checkpoints were positively correlated with CCR6 expression. Kaplan-Meier analyses showed that high CCR6 expression was associated with a good outcome in CM and its subtypes. Cox regression showed that CCR6 was an independent prognostic factor in patients with CM (HR = 0.550, 95% CI = 0.332-0.912, p<0.05). ConclusionsCCR6 is considered to be a new prognostic biomarker for patients with CM, and our study provides a potential therapeutic target for CM treatment.

cutaneous melanoma CCR6 TCGA database prognosis biomarker

SCI

英语

其他

Oncology

Oncology

WOS:000983009000001

FRONTIERS MEDIA SA

Web of Science

1.Guangzhou Med Univ, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China
2.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Plast & C, Shenzhen, Guangdong, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Operating R, Shenzhen, Guangdong, Peoples R China
4.Guangzhou Med Univ, Affiliated Hosp 1, Dept Plast Surg, Guangzhou, Guangdong, Peoples R China
5.Guangzhou Med Univ, Dept Allergy & Clin Immunol, Affiliated Hosp 1, Guangzhou, Peoples R China
6.Guangzhou Med Univ, Dept Canc, Affiliated Hosp 1, Guangzhou, Peoples R China

Nurzat, Yeltai,Dai, Damao,Hu, Julong,et al. Prognostic biomarker CCR6 and its correlation with immune infiltration in cutaneous melanoma[J]. FRONTIERS IN ONCOLOGY,2023,13.

Nurzat, Yeltai.,Dai, Damao.,Hu, Julong.,Zhang, Feiyu.,Lin, Zaihuan.,...&Zhang, Xiaowen.(2023).Prognostic biomarker CCR6 and its correlation with immune infiltration in cutaneous melanoma.FRONTIERS IN ONCOLOGY,13.

Nurzat, Yeltai,et al."Prognostic biomarker CCR6 and its correlation with immune infiltration in cutaneous melanoma".FRONTIERS IN ONCOLOGY 13(2023).