Red blood cell membrane-functionalized Nanofibrous tubes for small-diameter vascular grafts

Zhang, Chunliang1,2; Cha, Ruitao2; Wang, Chunyuan3; Chen, Xingming4; Li, Zulan4; Xie, Qian5; Jia, Liujun3; Sun, Yang3; Hu, Zhan3; Zhang, Lin6; Zhou, Fengshan1; Zhang, Yan3; Jiang, Xingyu7

2023-06-01

10.1016/j.biomaterials.2023.122124

BIOMATERIALS   影响因子和分区

0142-9612

1878-5905

The off-the-shelf small-diameter vascular grafts (SDVGs) have inferior clinical efficacy. Red blood cell membrane (Rm) has easy availability and multiple bioactive components (such as phospholipids, proteins, and glycopro-teins), which can improve the clinic's availability and patency of SDVGs. Here we developed a facile approach to preparing an Rm-functionalized poly-e-caprolactone/poly-D-lysine (Rm@PCL/PDL) tube by co-incubation and single-step rolling. The integrity, stability, and bioactivity of Rm on Rm@PCL/PDL were evaluated. The revas-cularization of Rm@PCL/PDL tubes was studied by implantation in the carotid artery of rabbits. Rm@PCL/PDL can be quickly prepared and showed excellent bioactivity with good hemocompatibility and great anti-inflammatory. Rm@PCL/PDL tubes as the substitute for the carotid artery of rabbits had good patency and quick remodeling within 21 days. Rm, as a "self" biomaterial with high biosafety, provides a new and facile approach to developing personalized or universal SDVGs for the clinic, which is of great significance in car-diovascular regenerative medicine and organ chip.

Small -diameter vascular graft Red blood cell membrane Electrospinning Poly epsilon-caprolactone Personalized therapy

SCI ; EI

英语

通讯

National Natural Science Foundation of China["32171397","21875050","82172099","32071390","81730051"] ; National Key R & D Program of China[2018YFA0902600] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000984264700001

ELSEVIER SCI LTD

20231713945839

Bioactivity ; Cytology ; Grafting (chemical) ; Grafts ; Phospholipids

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9 ; Prosthetics:462.4 ; Chemical Reactions:802.2 ; Organic Compounds:804.1

MATERIALS SCIENCE

Web of Science

1.China Univ Geosci Beijing, Sch Mat Sci & Technol, Beijing Key Lab Mat Utilizat Nonmet Minerals & Sol, Natl Lab Mineral Mat, 29 Xueyuan Rd, Beijing 100083, Peoples R China
2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, 167 Beilishi Rd, Beijing 100037, Peoples R China
4.PLA Strateg Support Force Characterist Med Ctr, 9 Anxiang Beili, Beijing 100101, Peoples R China
5.Peking Univ Third Hosp, Div Nephrol, 49 Huayuan Rd North, Beijing 100191, Peoples R China
6.Gen Hosp Peoples Liberat Army China, Fac Cardiovasc Dis, Med Ctr 6, Dept Adult Cardiac Surg, 28 Fuxing Rd, Beijing 100853, Peoples R China
7.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Guangdong Prov Key Lab Adv Biomat, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China

Zhang, Chunliang,Cha, Ruitao,Wang, Chunyuan,et al. Red blood cell membrane-functionalized Nanofibrous tubes for small-diameter vascular grafts[J]. BIOMATERIALS,2023,297.

Zhang, Chunliang.,Cha, Ruitao.,Wang, Chunyuan.,Chen, Xingming.,Li, Zulan.,...&Jiang, Xingyu.(2023).Red blood cell membrane-functionalized Nanofibrous tubes for small-diameter vascular grafts.BIOMATERIALS,297.

Zhang, Chunliang,et al."Red blood cell membrane-functionalized Nanofibrous tubes for small-diameter vascular grafts".BIOMATERIALS 297(2023).