Rhodium(i)-catalyzed N-arylation of arylazocarboxylates: facile access to unsymmetrical N,N-diarylhydrazides

Rao, Xiaofeng; Zhang, Wei-An; Xu, Ming-Hua1

2023-05-01

10.1039/d3nj01022h

NEW JOURNAL OF CHEMISTRY   影响因子和分区

1144-0546

1369-9261

A simple, efficient, and broad-scope rhodium(i)-catalyzed direct N-arylation of arylazocarboxylates with arylboronic acids has been developed, allowing access to a diverse range of unsymmetrical N,N-diarylhydrazides from readily available starting materials in high yields under extraordinary mild conditions. The reaction features easy operation, ambient temperature and low catalyst loading (as low as 0.1 mol%), as well as broad functional-group compatibility. The resulting N,N-diarylhydrazides could serve as versatile building blocks to furnish other structurally important or pharmaceutically interesting molecules. This protocol provides an attractive and complementary approach for the assembly of valuable N,N-diarylamine scaffolds.

SCI ; EI ; IC ; CCR

英语

通讯

National Natural Science Foundation of China[21971103] ; Natural Science Foundation of Guangdong Province[2021A1515012341] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Shenzhen Science and Technology Innovation Commission[JCYJ20200109141408054]

Chemistry

Chemistry, Multidisciplinary

WOS:000983740400001

ROYAL SOC CHEMISTRY

20232014109744

Aromatic compounds ; Catalysis ; Rhodium compounds ; Steel beams and girders

Construction Equipment:405.1 ; Structural Members and Shapes:408.2 ; Steel:545.3 ; Chemical Reactions:802.2 ; Organic Compounds:804.1

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China

Rao, Xiaofeng,Zhang, Wei-An,Xu, Ming-Hua. Rhodium(i)-catalyzed N-arylation of arylazocarboxylates: facile access to unsymmetrical N,N-diarylhydrazides[J]. NEW JOURNAL OF CHEMISTRY,2023,47(21):10147-10152.

Rao, Xiaofeng,Zhang, Wei-An,&Xu, Ming-Hua.(2023).Rhodium(i)-catalyzed N-arylation of arylazocarboxylates: facile access to unsymmetrical N,N-diarylhydrazides.NEW JOURNAL OF CHEMISTRY,47(21),10147-10152.

Rao, Xiaofeng,et al."Rhodium(i)-catalyzed N-arylation of arylazocarboxylates: facile access to unsymmetrical N,N-diarylhydrazides".NEW JOURNAL OF CHEMISTRY 47.21(2023):10147-10152.