Oral Ionic Liquid for Transdermal Delivery and Obesity Treatment

Lu, Beibei1,2,3,4,5; Wu, Chengyu4,5; Zhang, Jichuan6; Zhang, Jianglin1,2,3; Zhang, Jiaheng4,5

2023-04-01

10.1021/acsbiomaterials.3c00118

ACS BIOMATERIALS SCIENCE & ENGINEERING   影响因子和分区

2373-9878

Obesity is currently a prerequisite for more than 70% of adults, including chronic obesity and long-term obesity. With the increase of diabetes patients in the world, it is urgent to develop effective oral drugs to replace insulin. However, the gastrointestinal tract is a main obstacle to oral drug preparations. Here, a highly effective oral drug was developed, mainly formulated as an ionic liquid (IL) prepared by L-(-)-carnitine and geranic acid. Density functional theory (DFT) calculations showed that L-(-)-carnitine and geranic acid can exist stably through hydrogen bonding. IL can significantly enhance the transdermal transport of drugs. In vitro study of intestinal permeability showed that particles formed by IL can prevent the absorption of intestinal fat. Compared with the control group, oral administration of IL (10 mL kg-1) significantly reduced blood glucose, white adipose tissue in the liver and epididymis, and the expression of SREBP-1c and ACC in IL. Therefore, these results and high-throughput sequencing analysis showed that IL can effectively reduce the intestinal absorption of adipose tissue to reduce blood glucose. IL has good biocompatibility and stability. Therefore, IL has a certain application value in the field of oral drug-delivery carriers, which provides an effective means for the treatment of diabetes and is a potential tool to solve the epidemic of obesity.

l-(-)-carnitine geranic acid ionic liquid transdermal delivery obesity

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China["82073018","21703218"] ; Shenzhen Science and Technology Innovation Committee["JCYJ20180507183907224","KQTD20170809110344233"] ; Economic, Trade and Information Commission of Shenzhen Municipality through the Graphene Manufacture Innovation Center[201901161514] ; Guangdong Province Covid-19 Pandemic Control Research Fund[2020KZDZX1220]

Materials Science

Materials Science, Biomaterials

WOS:000984468900001

AMER CHEMICAL SOC

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Dermatol,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
2.Natl Clin Res Ctr Skin Dis, Candidate Branch, Shenzhen 518020, Guangdong, Peoples R China
3.Geriatr Ctr, Dept Shenzhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China
4.Harbin Inst Technol Shenzhen, Sauvage Lab Smart Mat, Shenzhen 518055, Peoples R China
5.Harbin Inst Technol Shenzhen, Res Ctr Printed Flexible Elect, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
6.Univ Idaho, Dept Chem, Moscow, ID 83844 USA

Lu, Beibei,Wu, Chengyu,Zhang, Jichuan,et al. Oral Ionic Liquid for Transdermal Delivery and Obesity Treatment[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2023,9(6).

Lu, Beibei,Wu, Chengyu,Zhang, Jichuan,Zhang, Jianglin,&Zhang, Jiaheng.(2023).Oral Ionic Liquid for Transdermal Delivery and Obesity Treatment.ACS BIOMATERIALS SCIENCE & ENGINEERING,9(6).

Lu, Beibei,et al."Oral Ionic Liquid for Transdermal Delivery and Obesity Treatment".ACS BIOMATERIALS SCIENCE & ENGINEERING 9.6(2023).