Development of Sulfonamide-Functionalized Charge-Reversal AIE Photosensitizers for Precise Photodynamic Therapy in the Acidic Tumor Microenvironment

Yang, Xueqin1,2,3; Xu, Changhuo1,2; Zhang, Xun4; Li, Pei1,2; Sun, Feiyi1,2; Liu, Xinyue1,2; Wang, Xinyuan1,2,4; Kwok, Ryan T. K.1,2; Yang, Jinglei1,2; Lam, Jacky W. Y.1,2; Liang, Yongye4; Tang, Ben Zhong1,2,5,6

2023-05-01

10.1002/adfm.202300746

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Tumor-targeted photodynamic therapy (PDT) is desirable as it can achieve efficient killing of tumor cells with no or less harm to normal cells. Herein, a facile molecular engineering strategy is developed for photosensitizers (PSs) with aggregation induced emission (AIE) characteristics and responsive properties to the acidic tumor microenvironment (TME). By the marriage of pH-sensitive sulfonamide moieties with AIE PSs, two near-infrared AIE luminogens called DBP-SPy and DBP-SPh are designed and synthesized. Both luminogens can form negatively charged nanoaggregates in the aqueous medium at physiological pH. The DBP-SPy nanoaggregates undergo surface charge conversion to become positive at pH close to the signature pH of TME, while DBP-SPh nanoaggregates show no such property. The endowed response to acidic TME enables the enhanced cellular uptake of DBP-SPy at pH = 6.8. By contrast, its cellular uptake is much sacrificed at pH 7.4. As a result, under white light irradiation, DBP-SPy nanoaggregates demonstrate a considerable photodynamic therapeutic effect on cancer cells in vitro and excellent tumor growth inhibition in vivo. Hence, this study not only provides an acidic TME-responsive AIE PS for precise PDT, but also inspires new design strategies for AIE-based theragnostic systems with targeting characteristics.

acidic tumor microenvironment aggregation-induced emission photosensitizers pH-responsibility targeted photodynamic therapy

SCI ; EI

英语

NI论文

其他

National Natural Science Foundation of China[21788102] ; Research Grants Council of Hong Kong["16306620","N-HKUST 609/19","C6014-20 W"] ; Innovation and Technology Commission[ITC-CNERC14SC01] ; Natural Science Foundation of Guangdong Province[2019B121205002]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000979744600001

WILEY-V C H VERLAG GMBH

20231914063064

Cancer cells ; Conversion efficiency ; Infrared devices ; pH ; Photodynamic therapy ; Sulfur compounds ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Energy Conversion Issues:525.5 ; Light/Optics:741.1 ; Chemistry, General:801.1

MATERIALS SCIENCE

Web of Science

1.Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Dept Chem, Dept Mech & Aerosp Engn,Kowloon,Hong Kong Branch, Clear Water Bay, Hong Kong 999077, Peoples R China
2.Hong Kong Univ Sci & Technol, Guangdong Hong Kong Macau Joint Lab Optoelect & Ma, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
3.Hong Kong Univ Sci & Technol Guangzhou, Biosci & Biomed Engn Thrust, Syst Hub, Guangzhou 511400, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
5.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China
6.South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, Guangzhou 510640, Guangdong, Peoples R China

Yang, Xueqin,Xu, Changhuo,Zhang, Xun,et al. Development of Sulfonamide-Functionalized Charge-Reversal AIE Photosensitizers for Precise Photodynamic Therapy in the Acidic Tumor Microenvironment[J]. ADVANCED FUNCTIONAL MATERIALS,2023,33(30).

Yang, Xueqin.,Xu, Changhuo.,Zhang, Xun.,Li, Pei.,Sun, Feiyi.,...&Tang, Ben Zhong.(2023).Development of Sulfonamide-Functionalized Charge-Reversal AIE Photosensitizers for Precise Photodynamic Therapy in the Acidic Tumor Microenvironment.ADVANCED FUNCTIONAL MATERIALS,33(30).

Yang, Xueqin,et al."Development of Sulfonamide-Functionalized Charge-Reversal AIE Photosensitizers for Precise Photodynamic Therapy in the Acidic Tumor Microenvironment".ADVANCED FUNCTIONAL MATERIALS 33.30(2023).