题名 | Serum proteome and metabolome uncover novel biomarkers for the assessment of disease activity and diagnosing of systemic lupus erythematosus |
作者 | |
通讯作者 | Dai, Yong |
发表日期 | 2023-06-01
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DOI | |
发表期刊 | |
ISSN | 1521-6616
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EISSN | 1521-7035
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卷号 | 251 |
摘要 | Systemic lupus erythematosus (SLE) is an autoimmune disease affecting thousands of people. There are still no effective biomarkers for SLE diagnosis and disease activity assessment. We performed proteomics and metabolomics analyses of serum from 121 SLE patients and 106 healthy individuals, and identified 90 proteins and 76 metabolites significantly changed. Several apolipoproteins and the metabolite arachidonic acid were significantly associated with disease activity. Apolipoprotein A-IV (APOA4), LysoPC(16:0), punicic acid and stearidonic acid were correlated with renal function. Random forest model using the significantly changed molecules identified 3 proteins including ATRN, THBS1 and SERPINC1, and 5 metabolites including cholesterol, palmitoleoylethanolamide, octadecanamide, palmitamide and linoleoylethanolamide, as potential biomarkers for SLE diagnosis. Those biomarkers were further validated in an independent cohort with high accuracy (AUC = 0.862 and 0.898 for protein and metabolite biomarkers respectively). This unbiased screening has led to the discovery of novel molecules for SLE disease activity assessment and SLE classification. |
关键词 | |
相关链接 | [来源记录] |
收录类别 | |
语种 | 英语
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学校署名 | 通讯
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资助项目 | Science and Technology Plan of Shenzhen[JCYJ20200109144218597]
; Shenzhen Key Medical Discipline Construction Fund[SZXK011]
; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Spe-cialties[SZGSP001]
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WOS研究方向 | Immunology
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WOS类目 | Immunology
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WOS记录号 | WOS:000983667300001
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出版者 | |
ESI学科分类 | IMMUNOLOGY
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来源库 | Web of Science
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引用统计 |
被引频次[WOS]:8
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成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/536293 |
专题 | 南方科技大学第一附属医院 |
作者单位 | 1.Guangzhou Tradit Chinese Med Univ, Shenzhen Tradit Chinese Med Hosp, Forth Clin Med Coll, Dept Radiotherapy, Shenzhen 518033, Peoples R China 2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Shenzhen Engn Re, Shenzhen 518020, Guangdong, Peoples R China 3.First Affiliated Hosp Jinan Univ, Dept Nephrol, Guangzhou 510630, Peoples R China 4.Biotree, Biotree Metabol Res Ctr, Jiading Dist, Shanghai 201800, Peoples R China 5.Cent South Univ, Xiangya Hosp 2, Dept Dermatol, Hunan Key Lab Med Epigen, Changsha 410011, Hunan, Peoples R China |
通讯作者单位 | 南方科技大学第一附属医院 |
推荐引用方式 GB/T 7714 |
He, Jingquan,Tang, Donger,Liu, Dongzhou,et al. Serum proteome and metabolome uncover novel biomarkers for the assessment of disease activity and diagnosing of systemic lupus erythematosus[J]. CLINICAL IMMUNOLOGY,2023,251.
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APA |
He, Jingquan.,Tang, Donger.,Liu, Dongzhou.,Hong, Xiaoping.,Ma, Chiyu.,...&Dai, Yong.(2023).Serum proteome and metabolome uncover novel biomarkers for the assessment of disease activity and diagnosing of systemic lupus erythematosus.CLINICAL IMMUNOLOGY,251.
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MLA |
He, Jingquan,et al."Serum proteome and metabolome uncover novel biomarkers for the assessment of disease activity and diagnosing of systemic lupus erythematosus".CLINICAL IMMUNOLOGY 251(2023).
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