Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy

Pan, Yanhong1,3; Wu, Weipeng2; Jiang, Xiaoxin1; Liu, Yunhong1

2023-07-01

10.1016/j.biopha.2023.114817

BIOMEDICINE & PHARMACOTHERAPY   影响因子和分区

0753-3322

1950-6007

Cardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem and have high morbidity and mortality worldwide, as well as substantial health and economic burdens, representing an urgent clinical need. In recent years, the focus of research has shifted from the use of mesenchymal stem cells (MSCs) for transplantation to the use of their secretory exosomes (MSC-exosomes) for the treatment of numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusion (I/R), aneurysm, and stroke. MSCs are pluripotent stem cells with multiple differentiation pathways that exert pleiotropic effects by producing soluble factors, the most effective components of which are exosomes. MSC-exosomes are considered to be an excellent and promising cell-free therapy for CVDs due to their higher circulating stability, improved biocompatibility, reduced toxicity, and immunogenicity. In addition, exosomes play critical roles in repairing CVDs by inhibiting apoptosis, regulating inflammation, ameliorating cardiac remodeling, and promoting angiogenesis. Herein, we describe knowledge about the biological characteristics of MSC-exosomes, investigate the mechanism by which MSC-exosomes mediate therapeutic repair, and summarize recent advances in the efficacy of MSCexosomes in CVDs, with a view toward future clinical applications.

Mesenchymal stem cells Exosomes Cardiovascular disease Cerebrovascular disease

SCI

英语

其他

Research & Experimental Medicine ; Pharmacology & Pharmacy

Medicine, Research & Experimental ; Pharmacology & Pharmacy

WOS:000993977500001

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Web of Science

1.Peoples Hosp Longhua Shenzhen, Dept Clin Lab, Shenzhen 518109, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Dept Clin Lab, Shenzhen Hosp, Shenzhen 518055, Guangdong, Peoples R China
3.Peoples Hosp Longhua Shenzhen, Dept Clin Lab, 38 Jianshe East Rd,Longhua St, Shenzhen 518109, Guangdong, Peoples R China

Pan, Yanhong,Wu, Weipeng,Jiang, Xiaoxin,et al. Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy[J]. BIOMEDICINE & PHARMACOTHERAPY,2023,163.

Pan, Yanhong,Wu, Weipeng,Jiang, Xiaoxin,&Liu, Yunhong.(2023).Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy.BIOMEDICINE & PHARMACOTHERAPY,163.

Pan, Yanhong,et al."Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy".BIOMEDICINE & PHARMACOTHERAPY 163(2023).