Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy

Liu，Guoyong1,2; Wang，Shuxian3; Wang，Shumin1; Wu，Rongrong4; Li，Hui1; Zha，Menglei3; Song，Jibin4; Yin，Yuxin1; Li，Kai3; Mu，Jing1; Shi，Yu2

2023-12-01

10.1186/s12951-023-01887-2

Journal of Nanobiotechnology   影响因子和分区

1477-3155

Background: Photothermal therapy (PTT) in the second near-infrared (NIR-II) window has attracted extensive attention due to the benefits in high maximum permissible exposure and penetration depth. Current photothermal agents generally show a broadband absorption accompanied by a gradual attenuation of absorption in the NIR-II window, leading to poor effect of PTT. It remains a great challenge to gain photothermal agents with strong and characteristic absorption in NIR-II regions. To overcome this problem, based on carbon dots (CDs)-mediated growth strategy, we proposed a simple and feasible approach to prepare plasmonic gold nanodendrites (AuNDs) with NIR-II absorption to enhance the therapeutic effect of PTT. Results: By rationally regulating the size and branch length of AuNDs, the AuNDs exhibited a broadband absorption from 300 to 1350 nm, with two characteristic absorption peaks located at 1077 and 1265 nm. The AuNDs demonstrated desired optical photothermal conversion efficiency (38.0%), which was further applied in NIR-II photoacoustic imaging (PAI) and PTT in human colon cancer cells (HCT 116)-tumor-bearing mice model. The tumor cells could be effectively eliminated in vivo under 1064 nm laser irradiation by the guidance of PAI. Conclusions: We reported a simple but powerful synthetic method to obtain the unique AuNDs with strong and characteristic absorption peaks in the NIR-II window. This study provides a promising solution to tuning the growth of nanoparticles for bioimaging and phototherapy in the NIR-II window. Graphical Abstract: [Figure not available: see fulltext.]

Carbon dots Gold nanodendrites Photoacoustic imaging Photothermal therapy Second near-infrared window

SCI ; EI

英语

通讯

Basic and Applied Basic Research Foundation of Guangdong Province[2023A1515012658];National Postdoctoral Program for Innovative Talents[BX20220215];Shenzhen Science and Technology Innovation Program[RCYX20221008092946108];

Biotechnology & Applied Microbiology ; Science & Technology - Other Topics

Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology

WOS:000985510700001

BMC

20232014082278

Cancer cells ; Carbon ; Conversion efficiency ; Gold ; Infrared devices ; Mammals ; Photoacoustic effect

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Energy Conversion Issues:525.5 ; Precious Metals:547.1 ; Light/Optics:741.1 ; Acoustic Waves:751.1 ; Chemical Products Generally:804

BIOLOGY & BIOCHEMISTRY

2-s2.0-85158931210

Scopus

1.Department of Nuclear Medicine,Peking University Shenzhen Hospital,Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center,Shenzhen,518036,China
2.Department of Ultrasound,Peking University Shenzhen Hospital,Peking University,Shenzhen,518036,China
3.Shenzhen Key Laboratory of Smart Healthcare Engineering,Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
4.MOE Key Laboratory for Analytical Science of Food Safety and Biology,College of Chemistry,Fuzhou University,Fuzhou,350108,China

Liu，Guoyong,Wang，Shuxian,Wang，Shumin,et al. Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy[J]. Journal of Nanobiotechnology,2023,21(1).

Liu，Guoyong.,Wang，Shuxian.,Wang，Shumin.,Wu，Rongrong.,Li，Hui.,...&Shi，Yu.(2023).Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy.Journal of Nanobiotechnology,21(1).

Liu，Guoyong,et al."Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy".Journal of Nanobiotechnology 21.1(2023).