Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea

Liang，Haoyu1; Song，Zhi Man1,2; Zhong，Zheng1; Zhang，Dengwei1,3; Yang，Wei4; Zhou，Le1,3; Older，Ethan A.5; Li，Jie5; Wang，Huan6; Zeng，Zhirui4; Li，Yong Xin1,3

2023-12-01

10.1186/s40168-023-01521-1

Microbiome   影响因子和分区

2049-2618

2049-2618

Background: Microbes produce diverse secondary metabolites (SMs) such as signaling molecules and antimicrobials that mediate microbe-microbe interaction. Archaea, the third domain of life, are a large and diverse group of microbes that not only exist in extreme environments but are abundantly distributed throughout nature. However, our understanding of archaeal SMs lags far behind our knowledge of those in bacteria and eukarya. Results: Guided by genomic and metabolic analysis of archaeal SMs, we discovered two new lanthipeptides with distinct ring topologies from a halophilic archaeon of class Haloarchaea. Of these two lanthipeptides, archalan α exhibited anti-archaeal activities against halophilic archaea, potentially mediating the archaeal antagonistic interactions in the halophilic niche. To our best knowledge, archalan α represents the first lantibiotic and the first anti-archaeal SM from the archaea domain. Conclusions: Our study investigates the biosynthetic potential of lanthipeptides in archaea, linking lanthipeptides to antagonistic interaction via genomic and metabolic analyses and bioassay. The discovery of these archaeal lanthipeptides is expected to stimulate the experimental study of poorly characterized archaeal chemical biology and highlight the potential of archaea as a new source of bioactive SMs. [MediaObject not available: see fulltext.]

SCI

英语

通讯

Research Grants Council, University Grants Committee[17115322];Research Grants Council, University Grants Committee[27107320];

Microbiology

Microbiology

WOS:000972332000001

BMC

2-s2.0-85152544246

Scopus

1.Department of Chemistry and The Swire Institute of Marine Science,The University of Hong Kong,Pokfulam Road,Hong Kong
2.Chemistry and Chemical Engineering Guangdong Laboratory,Shantou,515031,China
3.Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou),Guangzhou,China
4.Department of Ocean Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
5.Department of Chemistry and Biochemistry,University of South Carolina,Columbia,United States
6.State Key Laboratory of Coordination Chemistry,Chemistry and Biomedicine Innovation Center of Nanjing University,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing,China

Liang，Haoyu,Song，Zhi Man,Zhong，Zheng,et al. Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea[J]. Microbiome,2023,11(1).

Liang，Haoyu.,Song，Zhi Man.,Zhong，Zheng.,Zhang，Dengwei.,Yang，Wei.,...&Li，Yong Xin.(2023).Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea.Microbiome,11(1).

Liang，Haoyu,et al."Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea".Microbiome 11.1(2023).