Fabrication of carboxymethyl chitosan-strontium chondroitin sulfate composites for potential bone regeneration

Li，Meixin1,3; Xu，Lei1; Ma，Fenbo3; Tang，Bin3,4,5; Qin，Chenghe1,2

2023-06-01

10.1016/j.polymertesting.2023.108053

Polymer Testing   影响因子和分区

0142-9418

1873-2348

Large bone defects have been a major healthcare concern. These defects are difficult to heal because of the chronic inflammatory environment surrounding the injury area. Osteoconductive composites with anti-inflammatory effects could provide a substrate to support cell growth and guide bone defect repair. Here, we synthesized a biofunctional composite that combined carboxymethyl-chitosan (CMCS) and strontium chondroitin sulfate (SrCS), for potential use in bone regeneration. We hypothesized that the as-prepared CMCS-SrCS composites could stimulate osteogenic activity and suppress inflammatory responses. The resultant composites displayed uniformly porous structures and good swelling capacity. The effect of the composites on MC3T3-E1 cells was investigated in vitro and the live cells showed favorable viability. Moreover, the RT-PCR results indicated that the CMCS-SrCS composites could suppress inflammatory responses and promote the osteogenic differentiation of MC3T3-E1 cells. These results suggested the CMCS-SrCS composites should have osteoconductive characteristics. Thus, we believe that the developed CMCS-SrCS composites should be a promising skeletal candidate for regenerative engineering applications.

Bone regeneration Carboxymethyl chitosan Strontium chondroitin sulfate

SCI ; EI

英语

通讯

National Key Research and Development Program of China[2019YFA0906004];

Materials Science ; Polymer Science

Materials Science, Characterization & Testing ; Polymer Science

WOS:001000669500001

ELSEVIER SCI LTD

20232014088206

Bone ; Chitosan ; Defects ; Strontium compounds ; Sulfur compounds

Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Organic Compounds:804.1 ; Materials Science:951

MATERIALS SCIENCE

2-s2.0-85159074417

Scopus

1.Department of Orthopedics and Traumatology,Guangdong Second Provincial General Hospital,The Second Clinical Medical School of Southern Medical University,Guangzhou,466 Xingang Road C., Haizhu District,510317,China
2.Division of Orthopaedics and Traumatology,Department of Orthopaedics,Nanfang Hospital,The First Clinical Medical School of Southern Medical University,Guangzhou,1838 Guangzhou N., Baiyun District,510515,China
3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,China
4.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,China
5.Shenzhen Key Laboratory of Cell Microenvironment,China

Li，Meixin,Xu，Lei,Ma，Fenbo,et al. Fabrication of carboxymethyl chitosan-strontium chondroitin sulfate composites for potential bone regeneration[J]. Polymer Testing,2023,123.

Li，Meixin,Xu，Lei,Ma，Fenbo,Tang，Bin,&Qin，Chenghe.(2023).Fabrication of carboxymethyl chitosan-strontium chondroitin sulfate composites for potential bone regeneration.Polymer Testing,123.

Li，Meixin,et al."Fabrication of carboxymethyl chitosan-strontium chondroitin sulfate composites for potential bone regeneration".Polymer Testing 123(2023).