Electropolishing influence on biocompatibility of additively manufactured Ti-Nb-Ta-Zr: in vivo and in vitro

Luo，J. P.1,2,3; Lv，K. P.4; Tang，J. C.2; Wu，Z. Z.4; Liu，Y. L.2; Luo，J. T.5; Lai，Y. X.1; Yan，M.2,6

2023-05-01

10.1007/s10856-023-06728-0

Journal of Materials Science: Materials in Medicine   影响因子和分区

0957-4530

1573-4838

Balling defect of the additively manufactured titanium lattice implants easily leads to muscle tissue rejection, which might cause failure of implantation. Electropolishing is widely used in surface polishing of complex components and has potential to deal with the balling defect. However, a clad layer could be formed on the surface of titanium alloy after electropolishing, which may affect the biocompatibility of the metal implants. To manufacture lattice structured β-type Ti-Ni-Ta-Zr (TNTZ) for bio-medical applications, it is necessary to investigate the impact of electropolishing on material biocompatibility. In this study, animal experiments were conducted to investigate the in vivo biocompatibility of the as-printed TNTZ alloy with or without electropolishing; and proteomics technology was used to elaborate the results. The following conclusions were drawn: (a) a 30% oxalic acid electropolishing treatment was effective in solving balling defects, and ~21 nm amorphous clad layer would be formed on the surface of the material after polishing; (b) the electropolished TNTZ suggested decreased cell cytotoxicity and improved blood biocompatibility as compared to as-printed TNTZ; (c) the amorphous clad layer could make a barrier to prevent Ta and Zr ions from penetrating into the muscle tissue, and could form a good tissue regeneration at the implantation site during 4 weeks, indicating that the electropolished TNTZ has the potential as implants; and (d) the cells attached to the electropolished TNTZ showed higher antioxidant capacity but less proliferation than attached to as-printed TNTZ. Graphical Abstract: [Figure not available: see fulltext.].

SCI ; EI

英语

通讯

National Natural Science Foundation of China["51971108","52271032"] ; Key Research and Development Program of Jiangsu Province[K22251901] ; Shenzhen Science and Technology Innovation Commission[JCYJ20220818100612027]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000987959000001

SPRINGER

20232014100242

Additives ; Electrolytic polishing ; Medical applications ; Molecular biology ; Muscle ; Oxalic acid ; Tissue regeneration ; Titanium alloys

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Immunology:461.9.1 ; Titanium and Alloys:542.3 ; Chemical Agents and Basic Industrial Chemicals:803 ; Organic Compounds:804.1

MATERIALS SCIENCE

2-s2.0-85159150880

Scopus

1.Centre for Translational Medicine Research & Development,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China
2.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.Shenzhen Distinta Interfacial Technology Co. Ltd,Shenzhen,518106,China
4.Department of Interventional Radiology,Shenzhen People’s Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China
5.School of Physics and Opto-electronic Engineering,Shenzhen university,Shenzhen,518060,China
6.Jiaxing Research Institute,Southern University of Science and Technology,Jiaxing,314001,China

Luo，J. P.,Lv，K. P.,Tang，J. C.,et al. Electropolishing influence on biocompatibility of additively manufactured Ti-Nb-Ta-Zr: in vivo and in vitro[J]. Journal of Materials Science: Materials in Medicine,2023,34(5).

Luo，J. P..,Lv，K. P..,Tang，J. C..,Wu，Z. Z..,Liu，Y. L..,...&Yan，M..(2023).Electropolishing influence on biocompatibility of additively manufactured Ti-Nb-Ta-Zr: in vivo and in vitro.Journal of Materials Science: Materials in Medicine,34(5).

Luo，J. P.,et al."Electropolishing influence on biocompatibility of additively manufactured Ti-Nb-Ta-Zr: in vivo and in vitro".Journal of Materials Science: Materials in Medicine 34.5(2023).