Evaluation of left ventricular myocardial work in patients with hyperthyroidism with different heart rates with noninvasive pressure-strain loop based on two-dimensional speck tracking imaging

Liu，Qian1,2; Chen，Lixin1,2; Liu，Xiaohua1,2; Peng，Guijuan1,2; Zhong，Xiaofang1,2; Sheng，Yuanyuan1,2; Luo，Shuyu1,2; Huang，Yuxiang1,2; Xu，Jinfeng1,2; Liu，Yingying1,2

2023-04-01

10.21037/qims-22-534

Quantitative Imaging in Medicine and Surgery   影响因子和分区

2223-4292

2223-4306

Background: We investigated the application value of no-invasive myocardial work in evaluating left ventricular (LV) function in patients with hyperthyroidism. Methods: Sixty-five patients with an initial hyperthyroidism diagnosis were sorted into tachycardia (group TH1, n=31) and without tachycardia (group TH2, n=34) groups. Thirty healthy participants served as the control group (group CON). LV strain parameters and LV myocardial work parameters were evaluated at rest. Each parameter’s value in identifying myocardial damage was analyzed using receiver operating characteristic curves. The correlation of myocardial work parameters with global longitudinal strain (GLS), longitudinal peak strain dispersion (normalized by heart rate, PSD), and systolic blood pressure (SBP) was analyzed. Results: There was no difference in classic echocardiographic parameters between the groups. Compared with that in group CON, GLS decreased in groups TH1 and TH2 (TH1 17.99%±2.21% and TH2: 19.00%±2.85% vs. 20.27%±1.49%; both P<0.05); there was no significant difference between groups TH1 and TH2. PSD increased in groups TH1 and TH2 (TH1 73.13±19.51 ms and TH2 55.06±17.03 vs. 44.13±8.65 ms; both P<0.05); it was higher in group TH1 than in group TH2 (P<0.05). Myocardial global work efficiency (GWE) decreased in groups TH1 and TH2 {TH1 95% [interquartile range (IQR), 94–95%] and TH2 96% (IQR, 95–97%) vs. 97% (IQR, 96–97%); both P<0.05}; it was lower in group TH1 than in group TH2 (P<0.05). Global constructive work (GCW) decreased in group TH1 (1,865.29±284.13 vs. 2,030.33±252.52 mmHg%; P<0.05), but was not different from that in group TH2; there was no difference between groups TH2 and CON. Global wasted work (GWW) increased in groups TH1 and TH2 [TH1 83.00 (IQR, 74.00–97.00) mmHg% and TH2 69.50 (IQR, 51.25–84.25) vs. 50.50 (IQR, 40.75–65.25) mmHg%; both P<0.05]; it was higher in group TH1 than in group TH2 (P<0.05). The area under the GWE curve was the largest (area under the curve =0.835), and the optimal cutoff point was 96.5%, with a sensitivity of 0.83 and a specificity of 0.70. GWE and GCW were positively correlated with GLS and negatively correlated with PSD. GWW was negatively correlated with GLS and positively correlated with PSD. In group CON, GCW and GWW were positively correlated with SBP; GWE was not correlated with SBP. In groups TH1 and TH2, GCW was positively correlated with SBP, but not with GWW or GWE. Conclusions: Hyperthyroidism can significantly decrease the GWE and increase GWW of the left ventricle. This change is more pronounced in patients with tachycardia. Myocardial work could be a novel method for the evaluation of LV myocardial function in patients with hyperthyroidism.

Hyperthyroidism left ventricle myocardial work pressure-strain loop tachycardia

SCI

英语

通讯

National Natural Science Foundation of China[82102041] ; Project of Innovation of the Science and Technology Commission of Shenzhen City["JCYJ20190807145609482","JCYJ20210324113804013"]

Radiology, Nuclear Medicine & Medical Imaging

Radiology, Nuclear Medicine & Medical Imaging

WOS:000929423300001

AME PUBLISHING COMPANY

2-s2.0-85153500859

Scopus

1.Shenzhen Medical Ultrasound Engineering Center,Department of Ultrasound,Shenzhen People’s Hospital,Second Clinical Medical College,Jinan University,Shenzhen,China
2.First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,China

Liu，Qian,Chen，Lixin,Liu，Xiaohua,et al. Evaluation of left ventricular myocardial work in patients with hyperthyroidism with different heart rates with noninvasive pressure-strain loop based on two-dimensional speck tracking imaging[J]. Quantitative Imaging in Medicine and Surgery,2023,13(4):2248-2261.

Liu，Qian.,Chen，Lixin.,Liu，Xiaohua.,Peng，Guijuan.,Zhong，Xiaofang.,...&Liu，Yingying.(2023).Evaluation of left ventricular myocardial work in patients with hyperthyroidism with different heart rates with noninvasive pressure-strain loop based on two-dimensional speck tracking imaging.Quantitative Imaging in Medicine and Surgery,13(4),2248-2261.

Liu，Qian,et al."Evaluation of left ventricular myocardial work in patients with hyperthyroidism with different heart rates with noninvasive pressure-strain loop based on two-dimensional speck tracking imaging".Quantitative Imaging in Medicine and Surgery 13.4(2023):2248-2261.