Global incidence pattern and factors associated with common cutaneous reactions related to COVID-19 vaccination of 2.55 million participants in real-world settings: A systematic review and meta-analysis

Guo，Yang1; Cao，Xue Shan2; Yang，Hua Tong3,4; Zhou，Meng Ge5; Yu，Bo1

2023-02-10

10.7189/jogh.13.06008

Journal of global health   影响因子和分区

2047-2978

2047-2986

Background: Understanding the incidence pattern of cutaneous reactions is crucial for promoting COVID-19 vaccination. We aimed to report the global incidence pattern of, and factors associated with common cutaneous reactions related to COVID-19 vaccination in real-world settings. Methods: We searched five databases (PubMed, Web of Science, Embase, CNKI, and Wanfang) from inception to May 13, 2022, for studies reporting the incidence of common cutaneous reactions related to COVID-19 vaccines in real-world settings. The outcomes were the systematic skin reactions (rash and urticaria) and the local injection site reactions (pain, swelling, redness, and erythema). We conducted random-effects meta-analyses and explored associated factors using multi-step statistical analyses. Results: We included 35 studies and assessed 2 549 968 participants from 23 countries. The pooled incidence of overall systemic skin reactions was 3.8% (95% confidence interval (CI) = 2.4%-5.5%) with short duration (about one week). Specifically, the pooled incidence rates of rash and urticaria were 3.0% (95% CI = 2.1%-3.9%) and 1.1% (95% CI = 0.7%-1.5%), respectively. For overall local injection site reactions, the pooled incidence was 72.4% (95% CI = 65.7%-78.7%) with short duration (1 to 4.5 days). Except for local pain (72.2%, 95% CI = 65.3%-78.5%), other localized reactions had low incidence, including swelling (13.3%, 95% CI = 9.5%-17.7%), redness (11.5%, 95% CI = 5.7%-19.0%), and erythema (5.8%, 95% CI = 0.7%-15.4%). Geographically, different distribution patterns were observed for these reactions. Regarding associated factors, mRNA vaccines showed lower incidence of urticaria (P < 0.001). Asia population showed higher incidence of urticaria (P < 0.001). We observed lower incidence rates of overall local injection site reactions and pain among inactivated vaccines (P < 0.001). We found no significant difference among reactions between the first and the second dose of vaccines. Conclusions: We examined the global incidence pattern of common cutaneous reactions related to COVID-19 vaccination and found low incidence and short duration of systemic skin reactions and local injection site reactions (except for pain); discrepancies in these reactions were observed across different vaccine types. The cutaneous side effects related to COVID-19 vaccination do not seem to cause concern. Registration: PROSPERO: CRD42021258012.

SCI ; SSCI

英语

其他

National Natural Science Foundation of China[82103727] ; China Postdoctoral Science Foundation[2021M702221] ; Guangdong Basic and Applied Basic Research Foundation["2022A1515010957","2021A1515011558"] ; Shenzhen Sanming Project[SZSM201812059] ; Shenzhen Key Medical Discipline Construction Fund[SZXK040] ; Shenzhen Science and Technology Program[RCBS20210706092408008]

Public, Environmental & Occupational Health

Public, Environmental & Occupational Health

WOS:000963970500001

INT SOC GLOBAL HEALTH

2-s2.0-85147834427

Scopus

1.Department of Dermatology,Institute of Dermatology,Peking University Shenzhen Hospital,Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center,Shenzhen,China
2.College of Life Science and Oceanography,Shenzhen University,Shenzhen,China
3.Department of Statistics and Data Science,Southern University of Science and Technology,Shenzhen,China
4.Department of Statistics,University of California Berkeley,Berkeley,United States
5.Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,China

Guo，Yang,Cao，Xue Shan,Yang，Hua Tong,et al. Global incidence pattern and factors associated with common cutaneous reactions related to COVID-19 vaccination of 2.55 million participants in real-world settings: A systematic review and meta-analysis[J]. Journal of global health,2023,13.

Guo，Yang,Cao，Xue Shan,Yang，Hua Tong,Zhou，Meng Ge,&Yu，Bo.(2023).Global incidence pattern and factors associated with common cutaneous reactions related to COVID-19 vaccination of 2.55 million participants in real-world settings: A systematic review and meta-analysis.Journal of global health,13.

Guo，Yang,et al."Global incidence pattern and factors associated with common cutaneous reactions related to COVID-19 vaccination of 2.55 million participants in real-world settings: A systematic review and meta-analysis".Journal of global health 13(2023).