Lifestyle Factors, Genetic Risk, and Cardiovascular Disease Risk among Breast Cancer Survivors: A Prospective Cohort Study in UK Biobank

Peng，Hexiang1; Wang，Siyue1; Wang，Mengying1; Wang，Xueheng1; Guo，Huangda1; Huang，Jie2; Wu，Tao1

2023-02-01

10.3390/nu15040864

Nutrients   影响因子和分区

2072-6643

Background: Evidence is limited regarding the association between lifestyles and cardiovascular disease (CVD), and the extent to which healthy lifestyles could offset the genetic risk of CVD in females with breast cancer (BC). Methods: Females diagnosed as BC, who were free of CVD at baseline, from UK Biobank were included. Five modifiable lifestyle factors were considered to calculate the healthy lifestyle score, namely body mass index (BMI), smoking, alcohol drinking, dietary habits, and physical activity. The polygenetic risk score (PRS) was derived for coronary heart disease (CHD), ischemic stroke (IS), and heart failure (HF). Results: In 13,348 female BC survivors, there were 986 CVD events (736 CHD, 165 IS, and 353 HF) over a median of 8.01 years of follow-up. Participants with 4–5 healthy lifestyle components were associated with a decreased risk of incident CVD (HR: 0.50; 95%CI: 0.37, 0.66), CHD (HR: 0.49; 95%CI: 0.35, 0.69), IS (HR: 0.35; 95%CI: 0.19, 0.65), and HF (HR: 0.59; 95%CI: 0.36, 0.97), compared with those with 0–1 lifestyle components. Evidence for the genetic–lifestyle interaction was observed for CHD (p = 0.034) and HF (p = 0.044). Among participants at high genetic risk, a healthy lifestyle was associated with a lower risk of CHD (HR: 0.37; 95%CI: 0.24, 0.56), IS (HR: 0.37; 95%CI: 0.15, 0.93) and HF (HR: 0.39; 95%CI: 0.21, 0.73). Conclusions: Our findings suggest that BC survivors with a high genetic risk could benefit more from adherence to a healthy lifestyle in reducing CVD risk.

breast cancer cardiovascular disease genetic risk lifestyle factors

SCI

英语

通讯

National Key Research and Development Program of China[2020YFC2002900];China Postdoctoral Science Foundation[2022M710249];National Natural Science Foundation of China[81872695];China Postdoctoral Science Foundation[BX2021021];

Nutrition & Dietetics

Nutrition & Dietetics

WOS:000940962900001

MDPI

2-s2.0-85148891447

Scopus

1.Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing,100191,China
2.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,518055,China

Peng，Hexiang,Wang，Siyue,Wang，Mengying,et al. Lifestyle Factors, Genetic Risk, and Cardiovascular Disease Risk among Breast Cancer Survivors: A Prospective Cohort Study in UK Biobank[J]. Nutrients,2023,15(4).

Peng，Hexiang.,Wang，Siyue.,Wang，Mengying.,Wang，Xueheng.,Guo，Huangda.,...&Wu，Tao.(2023).Lifestyle Factors, Genetic Risk, and Cardiovascular Disease Risk among Breast Cancer Survivors: A Prospective Cohort Study in UK Biobank.Nutrients,15(4).

Peng，Hexiang,et al."Lifestyle Factors, Genetic Risk, and Cardiovascular Disease Risk among Breast Cancer Survivors: A Prospective Cohort Study in UK Biobank".Nutrients 15.4(2023).