Association between different adiposity measures and all-cause mortality risk among centenarians: A prospective cohort study

Liu，Shaohua1; Cao，Wenzhe2; Li，Zhiqiang3,4; Wang，Shengshu1; Yang，Shanshan5; Lu，Mingming1; Li，Haowei1; Song，Yang1; Chen，Shimin1; Li，Xuehang1; Li，Rongrong1; Wang，Jianhua1; Yang，Junhan1; Liu，Miao6; He，Yao1

2023

10.1016/j.clnu.2023.04.023

Clinical Nutrition   影响因子和分区

0261-5614

1532-1983

Importance: Little evidence on the association between adiposity measures and all-cause mortality was observed among centenarians, and no targeted development of optimal weight recommendations for them. Objective: To comprehensively assess the association between adiposity indices and all-cause mortality among centenarians. Design setting, and participants: This prospective population-based cohort study included 1002 centenarians registered in 18 counties and cities in Hainan Province from June 2014 to May 2021. The age of participants at baseline was provided by the civil affairs bureau and verified before enrollment. Main outcomes and measures: All-cause mortality was rigorously confirmed as the primary outcome. BMI was calculated by height and weight. BRI was calculated by height and waist circumference. Results: At baseline, the mean (SD) age was 102.8 ± 2.7 years, and 180 participants (18.0%) were men. The median follow-up time was 5.0 (4.8–5.5) years, with 522 deaths. In BMI categories, compared with the lowest group (mean BMI = 14.2 kg/m), the highest group (mean BMI = 22.2 kg/m) had lower mortality (hazard ratio [HR], 0.61; 95%CI, 0.47–0.79) (P for trend = 0.001). In BRI categories, compared with the lowest group (mean BRI = 2.3), the highest group (mean BRI = 5.7) had lower mortality (hazard ratio [HR], 0.66; 95%CI, 0.51–0.85) (P for trend = 0.002), and the risk did not decrease after BRI exceeded 3.9 in women. Higher BRI was associated with lower HRs after adjusting for interaction with comorbidities status. E-values analysis suggested robustness to unmeasured confounding. Conclusions and relevance: BMI and BRI were inverse linear associated with mortality risk in the whole population, while BRI was observed to be J-shaped in women. The interaction of lower multiple complication incidence and BRI had a significant effect on the reduced risk of all-cause mortality.

Adiposity measure Centenarian Mortality Obesity

SCI

英语

其他

null[82173590]

Nutrition & Dietetics

Nutrition & Dietetics

WOS:001053760500001

CHURCHILL LIVINGSTONE

CLINICAL MEDICINE

2-s2.0-85160221450

Scopus

1.Beijing Key Laboratory of Aging and Geriatrics,National Clinical Research Center for Geriatrics Diseases,Institute of Geriatrics,Second Medical Center of Chinese People's Liberation Army (PLA) General Hospital,PLA Medical School,Beijing,China
2.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
3.School of Public Health,China Medical University,Shenyang,110122,China
4.Center for Disease Control and Prevention of Chinese People's Liberation Army,Beijing,100071,China
5.Department of Disease Prevention and Control,The 1st Medical Center,Chinese PLA General Hospital,Beijing,China
6.Department of Statistics and Epidemiology,Graduate School of Chinese PLA General Hospital & Chinese PLA Medical Academy,Beijing,100853,China

Liu，Shaohua,Cao，Wenzhe,Li，Zhiqiang,et al. Association between different adiposity measures and all-cause mortality risk among centenarians: A prospective cohort study[J]. Clinical Nutrition,2023,42(7).

Liu，Shaohua.,Cao，Wenzhe.,Li，Zhiqiang.,Wang，Shengshu.,Yang，Shanshan.,...&He，Yao.(2023).Association between different adiposity measures and all-cause mortality risk among centenarians: A prospective cohort study.Clinical Nutrition,42(7).

Liu，Shaohua,et al."Association between different adiposity measures and all-cause mortality risk among centenarians: A prospective cohort study".Clinical Nutrition 42.7(2023).