Identification of a seven-lncRNAs panel that serves as a prognosis predictor and contributes to the malignant progression of laryngeal squamous cell carcinoma

Zheng，Xiwang1,2; Gao，Wei3,4; Zhang，Zhe1,5; Xue，Xuting1,2; Mijiti，Maierhaba1; Guo，Qingbo1; Wusiman，Dilinaer6; Wang，Kai7; Zeng，Xianhai3,4; Xue，Lingbin3,4; Guo，Zekun8; An，Changming6; Wu，Yongyan3,4

2023

10.3389/fonc.2023.1106249

Frontiers in Oncology   影响因子和分区

2234-943X

2234-943X

Background: Laryngeal squamous cell carcinoma (LSCC) is one of the most frequent head and neck cancers worldwide. Long non-coding RNAs (lncRNAs) play a critical role in tumorigenesis. However, the clinical significance of lncRNAs in LSCC remains largely unknown. Methods: In this study, transcriptome sequencing was performed on 107 LSCC and paired adjacent normal mucosa (ANM) tissues. Furthermore, RNA expression and clinical data of 111 LSCC samples were obtained from The Cancer Genome Atlas (TCGA) database. Bioinformatics analysis were performed to construct a model for predicting the overall survival (OS) of LSCC patients. Moreover, we investigated the roles of lncRNAs in LSCC cells through loss-of-function experiments. Results: A seven-lncRNAs panel including ENSG00000233397, BARX1-DT, LSAMP-AS1, HOXB-AS4, MNX1-AS1, LINC01385, and LINC02893 was identified. The Kaplan–Meier analysis demonstrated that the seven-lncRNAs panel was significantly associated with OS (HR:6.21 [3.27-11.81], p-value<0.0001), disease-specific survival (DSS) (HR:4.34 [1.83-10.26], p-value=0.0008), and progression-free interval (PFI) (HR:3.78 [1.92-7.43], p-value=0.0001). ROC curves showed the seven-lncRNAs panel predicts OS with good specificity and sensitivity. Separately silencing the seven lncRNAs inhibited the proliferation, migration, and invasion capacity of LSCC cells. Conclusion: Collectively, this seven-lncRNAs panel is a promising signature for predicting the prognosis of LSCC patients, and these lncRNAs could serve as potential targets for LSCC treatment.

biomarker laryngeal squamous cell carcinoma long non-coding RNA oncogene prognosis

SCI

英语

其他

Natural Science Foundation of Shanxi Province[201805D211007];Natural Science Foundation of Shanxi Province[20210302124088];National Natural Science Foundation of China[82073101];National Natural Science Foundation of China[82172961];Shenzhen Key Laboratory Fund[ZDSYS20200811143757022];

Oncology

Oncology

WOS:000988162900001

FRONTIERS MEDIA SA

2-s2.0-85159898112

Scopus

1.Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer,First Hospital of Shanxi Medical University,Taiyuan,Shanxi,China
2.Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer,First Hospital of Shanxi Medical University,Taiyuan,Shanxi,China
3.Department of Otolaryngology Head & Neck Surgery,Longgang Otolaryngology Hospital,Shenzhen,Guangdong,China
4.Shenzhen Institute of Otolaryngology & Key Laboratory of Otolaryngology,Longgang Otolaryngology Hospital,Shenzhen,Guangdong,China
5.Shenzhen Eye Hospital,Jinan University,Shenzhen Eye Institute,Shenzhen,Guangdong,China
6.Department of Head and Neck Surgery,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
7.Department of Otolaryngology Head & Neck Surgery,Southern University of Science and Technology Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,China
8.College of Life Sciences,Northwest A&F University,Yangling,Shaanxi,China

Zheng，Xiwang,Gao，Wei,Zhang，Zhe,et al. Identification of a seven-lncRNAs panel that serves as a prognosis predictor and contributes to the malignant progression of laryngeal squamous cell carcinoma[J]. Frontiers in Oncology,2023,13.

Zheng，Xiwang.,Gao，Wei.,Zhang，Zhe.,Xue，Xuting.,Mijiti，Maierhaba.,...&Wu，Yongyan.(2023).Identification of a seven-lncRNAs panel that serves as a prognosis predictor and contributes to the malignant progression of laryngeal squamous cell carcinoma.Frontiers in Oncology,13.

Zheng，Xiwang,et al."Identification of a seven-lncRNAs panel that serves as a prognosis predictor and contributes to the malignant progression of laryngeal squamous cell carcinoma".Frontiers in Oncology 13(2023).