Prevalence of familial hypercholesterolemia and its association with coronary artery disease: A Chinese cohort study

Aihaiti，Xiapikatijiang1,2; Chen，Shufeng1; Li，Jianxin1; Lin，Zhennan1; Cui，Qingmei1; Xia，Xue1,3; Liu，Fangchao1; Shen，Chong4; Hu，Dongsheng5,6; Huang，Keyong1; Zhao，Yingxin7; Lu，Fanghong7; Liu，Xiaoqing8; Cao，Jie1; Yu，Ling9; Li，Ying1; Zhang，Huan10; Fu，Zhenyan11; Zhao，Liancheng1; Huang，Jianfeng1; Gu，Dongfeng1,12; Lu，Xiangfeng1,2

2023

10.1002/cdt3.69

Chronic Diseases and Translational Medicine   影响因子和分区

2095-882X

Background: Familial hypercholesterolemia (FH) is underrecognized, and its association with coronary artery disease (CAD) remains limited, especially in China. We aim to investigate the prevalence of FH and its relationship with CAD in a large Chinese cohort. Methods: FH was defined using the Make Early Diagnosis to Prevent Early Death (MEDPED) criteria. The crude and age-sex standardized prevalence of FH were calculated based on surveys of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project during 2007−2008. The associations of FH with incident CAD and its major subtypes were estimated with the cohort-stratified multivariate Cox proportional hazard models based on the data from the baseline to the last follow-up (2018−2020). Results: Among 98,885 included participants, 190 participants were defined as FH. Crude and age−sex standardized prevalence and 95% confidence interval (CI) of FH were 0.19% (0.17%–0.22%) and 0.13% (0.10%–0.16%), respectively. The prevalence varied across age groups and peaked in the group of 60–<70 years (0.28%), and the peak prevalence (0.18%) in males was earlier, yet lower than the peak crude prevalence in females (0.41%). During a mean follow-up of 10.7 years, 2493 cases of incident CAD were identified. After multivariate adjustment, FH patients had a 2.03-fold greater risk of developing CAD compared to non-FH participants. Conclusions: The prevalence of FH was estimated to be 0.19% in the participants, and it was associated with an elevated risk of incident CAD. Our study suggests that early screening of FH has certain public health significance for the prevention of CAD.

cohort study coronary artery disease familial hypercholesterolemia prevalence

英语

其他

2-s2.0-85153630262

Scopus

1.Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
2.Key Laboratory of Cardiovascular Epidemiology,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China
3.China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital,Capital Medical University,Bejing,China
4.Department of Epidemiology and Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,China
5.School of Public Health,Zhengzhou University,Zhengzhou,China
6.School of Public Health,Shenzhen University,Shenzhen,China
7.Cardio-Cerebrovascular Control and Research Center,Institute of Basic Medicine,Shandong Academy of Medical Sciences,Jinan,China
8.Division of Epidemiology,Guangdong Provincial People's Hospital Guangdong Cardiovascular Institute,Guangzhou,China
9.Department of Cardiology,Fujian Provincial People's Hospital,Fuzhou,China
10.Center for Genetic Epidemiology and Genomics,School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases,Soochow University Medical College,Suzhou,China
11.Department of Cardiology,First Affiliated Hospital of Xinjiang Medical University,Urumqi,China
12.School of Medicine,Southern University of Science and Technology,Shenzhen,China

Aihaiti，Xiapikatijiang,Chen，Shufeng,Li，Jianxin,et al. Prevalence of familial hypercholesterolemia and its association with coronary artery disease: A Chinese cohort study[J]. Chronic Diseases and Translational Medicine,2023.

Aihaiti，Xiapikatijiang.,Chen，Shufeng.,Li，Jianxin.,Lin，Zhennan.,Cui，Qingmei.,...&Lu，Xiangfeng.(2023).Prevalence of familial hypercholesterolemia and its association with coronary artery disease: A Chinese cohort study.Chronic Diseases and Translational Medicine.

Aihaiti，Xiapikatijiang,et al."Prevalence of familial hypercholesterolemia and its association with coronary artery disease: A Chinese cohort study".Chronic Diseases and Translational Medicine (2023).