Inbreeding depression in an outbred stickleback population

Fraimout，Antoine1,2; Rastas，Pasi3; Lv，Lei2,4; Merilä，Juha1,2

2023

10.1111/mec.16946

Molecular Ecology   影响因子和分区

0962-1083

1365-294X

Inbreeding depression refers to the reduced fitness of offspring produced by genetically-related individuals and is expected to be rare in large, outbred populations. When it occurs, marked fitness loss is possible as large populations can carry a substantial load of recessive harmful mutations which are normally sheltered at the heterozygous state. Using experimental cross data and genome-wide identity-by-descent (IBD) relationships from an outbred marine nine-spined stickleback (Pungitius pungitius) population, we documented a significant decrease in offspring survival probability with increasing parental IBD sharing associated with an average inbreeding load (B) of 10.5. Interestingly, we found that this relationship was also underlined by a positive effect of paternal inbreeding coefficient on offspring survival, suggesting that certain combinations of parental inbreeding and genetic relatedness among mates may promote offspring survival. Our results demonstrate the potential for substantial inbreeding load in an outbred population and emphasize the need to consider fine-scale genetic relatedness in future studies of inbreeding depression in the wild.

heritability IBD inbreeding inbreeding load Pungitius pungitius survival

SCI

英语

其他

Academy of Finland["129662","134728","218343"] ; Academy of Finland (AKA)[218343]

Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology

Biochemistry & Molecular Biology ; Ecology ; Evolutionary Biology

WOS:000969149600001

WILEY

ENVIRONMENT/ECOLOGY

2-s2.0-85152391721

Scopus

1.Ecological Genetics Research Unit,Organismal and Evolutionary Biology Research Programme,Faculty of Biological and Environmental Sciences,University of Helsinki,Helsinki,Finland
2.Area of Ecology and Biodiversity,School of Biological Sciences,The University of Hong Kong,Hong Kong
3.Institute of Biotechnology,University of Helsinki,Helsinki,Finland
4.School of Environmental Science and Engineering,Southern University of Science and Technology,Shenzhen,China

Fraimout，Antoine,Rastas，Pasi,Lv，Lei,et al. Inbreeding depression in an outbred stickleback population[J]. Molecular Ecology,2023,32(13).

Fraimout，Antoine,Rastas，Pasi,Lv，Lei,&Merilä，Juha.(2023).Inbreeding depression in an outbred stickleback population.Molecular Ecology,32(13).

Fraimout，Antoine,et al."Inbreeding depression in an outbred stickleback population".Molecular Ecology 32.13(2023).