A clinical study of C arm-guided selective spinal nerve block combined with low-temperature plasma radiofrequency ablation of dorsal root ganglion in the treatment of zoster-related neuralgia

Zhang，Zhen Wu; Zhao，Yan; Du，Tian Yi; Zhang，Juan; Wu，Qiong; Wang，Zhe Yin

2023

10.3389/fneur.2023.1122538

Frontiers in Neurology   影响因子和分区

1664-2295

1664-2295

Background: This study evaluated the analgesic efficacy and psychological response of low-temperature plasma ablation of dorsal root ganglion (DRG) combined with selective spinal nerve block in patients with acute or subacute zoster-related neuralgia (ZRN). Methods: Totally 90 ZRN patients were randomly and evenly divided into three groups. Treatment was given to Group A using C arm-guided selective spinal nerve block (C-SSVB), Group B using C-SSVB and pulsed radiofrequency (PRF), and Group C using C-SSVB and low-temperature plasma ablation of the DRG. The outcomes were examined using the Visual Analog Scale (VAS). Anxiety and depression of patients were evaluated using the Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS). Quality of life was assessed using the Pittsburgh Sleep Quality Index (PSQI) and postoperative Satisfaction scale. In addition, data on adverse events and medication usage rates were collected. Results: The 90 patients were eligible for this study. The three treatments reduced VAS scores with no significant difference between groups A and B at the same time points; however, group B tended to have numerically lower VAS scores. Comparatively, group C had significantly reduced VAS scores on day 1 and 1 month after treatment compared with the other two groups. In terms of the decreasing SAS, SDS and PSQI scores, all the three treatments improved the anxiety, depression and sleep quality of the patients. In addition, significant alleviation in anxiety was found in group C compared with group A at all- time points. However, there was no statistically significant difference among the three groups in treatment-related adverse events that mainly focused on puncture pain at the surgical-site, skin numbness and medication usage rates. Conclusions: C-SSVB and LTPRA of DRG will be considered as a promising treatment option for ZRN patients if those results can be confirmed after further validation.

analgesic efficacy low-temperature plasma radiofrequency ablation psychological response selective spinal nerve block zoster-related neuralgia

SCI

英语

第一

Neurosciences & Neurology

Clinical Neurology ; Neurosciences

WOS:000946229100001

FRONTIERS MEDIA SA

2-s2.0-85149844039

Scopus

Department of Pain Medicine,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,China

Zhang，Zhen Wu,Zhao，Yan,Du，Tian Yi,et al. A clinical study of C arm-guided selective spinal nerve block combined with low-temperature plasma radiofrequency ablation of dorsal root ganglion in the treatment of zoster-related neuralgia[J]. Frontiers in Neurology,2023,14.

Zhang，Zhen Wu,Zhao，Yan,Du，Tian Yi,Zhang，Juan,Wu，Qiong,&Wang，Zhe Yin.(2023).A clinical study of C arm-guided selective spinal nerve block combined with low-temperature plasma radiofrequency ablation of dorsal root ganglion in the treatment of zoster-related neuralgia.Frontiers in Neurology,14.

Zhang，Zhen Wu,et al."A clinical study of C arm-guided selective spinal nerve block combined with low-temperature plasma radiofrequency ablation of dorsal root ganglion in the treatment of zoster-related neuralgia".Frontiers in Neurology 14(2023).