Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells

Liu，Xi1; Wei，Qian1; Lu，Lu2; Cui，Shengnan1,3; Ma，Kui1,4; Zhang，Wenhua1; Ma，Fang5; Li，Haihong6; Fu，Xiaobing1,4; Zhang，Cuiping1,4

2023

cell dysfunction extracellular vesicles immune cells inflammatory diseases mesenchymal stem cells

英语

National Natural Science Foundation of China[22205260];National Natural Science Foundation of China[81830064];National Natural Science Foundation of China[82172211];National Natural Science Foundation of China[82172231];

Various intractable inflammatory diseases caused by disorders of immune systems have pressed heavily on public health. Innate and adaptive immune cells as well as secreted cytokines and chemokines are commanders to mediate our immune systems. Therefore, restoring normal immunomodulatory responses of immune cells is crucial for the treatment of inflammatory diseases. Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) are nano-sized double-membraned vesicles acting as paracrine effectors of MSCs. MSC-EVs, containing a variety of therapeutic agents, have shown great potential in immune modulation. Herein, we discuss the novel regulatory functions of MSC-EVs from different sources in the activities of innate and adaptive immune cells like macrophages, granulocytes, mast cells, natural killer (NK) cells, dendritic cells (DCs) and lymphocytes. Then, we summarize the latest clinical trials of MSC-EVs in inflammatory diseases. Furthermore, we prospect the research trend of MSC-EVs in the field of immune modulation. Despite the fact that the research on the role of MSC-EVs in regulating immune cells is in infancy, this cell-free therapy based on MSC-EVs still offers a promising solution for the treatment of inflammatory diseases.

10.3389/fimmu.2023.1094685

Frontiers in Immunology

14

SCI

通讯

2-s2.0-85149421849

Scopus

WOS:000939552400001

1664-3224

1.Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and the 4th Medical Center of Chinese PLA General Hospital,Beijing,China
2.Institute of NBC Defence,PLA Army,Beijing,China
3.Department of Dermatology,China Academy of Chinese Medical Science,Xiyuan Hospital,Beijing,China
4.Research Unit of Trauma Care,Tissue Repair and Regeneration,Chinese Academy of Medical Sciences,Beijing,China
5.Department of Ophthalmology,Beijing Chaoyang Hospital,Capital Medical University,Beijing,China
6.Department of Wound Repair,Institute of Wound Repair and Regeneration Medicine,Southern University of Science and Technology Hospital,Southern University of Science and Technology School of Medicine,Shenzhen,China

Liu，Xi,Wei，Qian,Lu，Lu,et al. Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells. 2023-01-01.