Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry

Zhan，Bo1; Zhu，Yingxin1; Xia，Jianxun2; Li，Wenfu1; Tang，Ying3; Beesetty，Anju4; Ye，Jiang Hong4; Fu，Rao1

2023

10.3390/ijms24010388

International Journal of Molecular Sciences   影响因子和分区

1661-6596

1422-0067

Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are prevalent neuropsychiatric disorders and frequently co-occur concomitantly. Individuals suffering from this dual diagnosis often exhibit increased symptom severity and poorer treatment outcomes than those with only one of these diseases. Lacking standard preclinical models limited the exploration of neurobiological mechanisms underlying PTSD and AUD comorbidity. In this review, we summarize well-accepted preclinical model paradigms and criteria for developing successful models of comorbidity. We also outline how PTSD and AUD affect each other bidirectionally in the nervous nuclei have been heatedly discussed recently. We hope to provide potential recommendations for future research.

amygdala animal model comorbid PTSD and AUD dopamine hippocampus locus coeruleus mesolimbic reward circuit paraventricular nuclei the prefrontal cortex ventral tegmental area

SCI

英语

其他

Natural Science Foundation of Guangdong Province[2021A1515010463];Shenzhen Science and Technology Innovation Program[202205303001697];Young Teacher Foundation of Sun Yat-sen University[59000-18841219];National Natural Science Foundation of China[82071496];

Biochemistry & Molecular Biology ; Chemistry

Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary

WOS:000908899600001

MDPI

CHEMISTRY

2-s2.0-85145966760

Scopus

1.Department of Anatomy,School of Medicine,Sun Yat-sen University,Shenzhen,Shenzhen Campus of Sun Yat-sen University,518107,China
2.Department of Basic Medical Sciences,Yunkang School of Medicine and Health,Nanfang College,Guangzhou,510970,China
3.Department of Biology,School of Life Science,Southern University of Science and Technology,Shenzhen,518055,China
4.Department of Anesthesiology,Pharmacology,Physiology Neuroscience,Rutgers,New Jersey Medical School,The State University of New Jersey,Newark,07103,United States

Zhan，Bo,Zhu，Yingxin,Xia，Jianxun,et al. Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry[J]. International Journal of Molecular Sciences,2023,24(1).

Zhan，Bo.,Zhu，Yingxin.,Xia，Jianxun.,Li，Wenfu.,Tang，Ying.,...&Fu，Rao.(2023).Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry.International Journal of Molecular Sciences,24(1).

Zhan，Bo,et al."Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry".International Journal of Molecular Sciences 24.1(2023).