Autophagy, cell death, and cytokines in K. pneumoniae infection: therapeutic perspectives

Wei，Sha1; Xu，Tingting1; Chen，Yuxin2; Zhou，Kai1

2023

10.1080/22221751.2022.2140607

Emerging Microbes and Infections   影响因子和分区

2222-1751

Klebsiella pneumoniae is a notorious nosocomial pathogen causing a wide range of infections. The increasing trend of antimicrobial resistance obtained by the species immensely highly challenges the clinical treatment, representing a large threat to the global health care network. In particular, the recent convergence of multidrug resistance and hypervirulence in K. pneumoniae further worsens clinical outcomes, resulting in high mortality. Developments of new therapeutics become urgent, and immunotherapy based on antagonizing the anti-immune strategies of pathogens is a promising strategy, which requires the understanding of immune evasion mechanism in the context of the host–pathogen interactions. However, the underlying mechanisms employed by K. pneumoniae to counteract host immune responses, especially autophagy and cell death, have not been systematically reviewed and discussed yet. This review aims to summarize the tremendous progress that has been made to illuminate the landscape of cell signalling triggered by K. pneumoniae infection, especially in aspects of manipulating autophagy, cell death, and cytokine production.

apoptosis autophagy cytokines Klebsiella pneumoniae necrosis pyroptosis

SCI

英语

第一 ; 通讯

Shenzhen Fundamental Research Program[JCYJ20190807144409307];

Immunology ; Infectious Diseases ; Microbiology

Immunology ; Infectious Diseases ; Microbiology

WOS:000900772900001

TAYLOR & FRANCIS LTD

2-s2.0-85144556440

Scopus

1.Shenzhen Institute of Respiratory Diseases,Second Clinical Medical College,Shenzhen People's Hospital,Jinan University,First Affiliated Hospital,Shenzhen People's Hospital,Southern University of Science and Technology,Shenzhen,China
2.Department of Laboratory Medicine,Nanjing Drum Tower Hospital Clinical College of Jiangsu University,Nanjing,China

Wei，Sha,Xu，Tingting,Chen，Yuxin,et al. Autophagy, cell death, and cytokines in K. pneumoniae infection: therapeutic perspectives[J]. Emerging Microbes and Infections,2023,12(1).

Wei，Sha,Xu，Tingting,Chen，Yuxin,&Zhou，Kai.(2023).Autophagy, cell death, and cytokines in K. pneumoniae infection: therapeutic perspectives.Emerging Microbes and Infections,12(1).

Wei，Sha,et al."Autophagy, cell death, and cytokines in K. pneumoniae infection: therapeutic perspectives".Emerging Microbes and Infections 12.1(2023).