A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging

Lu，Hongwei1; Chen，An2; Zhang，Xindan1; Wei，Zixiang1; Cao，Rong2; Zhu，Yi2; Lu，Jingxiong1; Wang，Zhongling2; Tian，Leilei1

2022-12-01

10.1038/s41467-022-35655-x

Nature Communications   影响因子和分区

2041-1723

Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO@MnO, which shows decreased T and T contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO) layer decomposes into magnetically active Mn (T-weighted), and the T and T signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T and T images can be accurately regulated by the silicon dioxide (SiO) intermediate layer between superparamagnetic iron oxide (SPIO) and MnO. Through the “dual-contrast enhanced subtraction” imaging processing technique, the contrast sensitivity of this MRI contrast agent is enhanced to a 12.3-time difference between diseased and normal tissue. Consequently, SPIO@SiO@MnO is successfully applied to trace the tiny liver metastases of approximately 0.5 mm and monitor tissue inflammation.

SCI

英语

NI论文

第一 ; 通讯

Science, Technology and Innovation Commission of Shenzhen Municipality[KQTD20170810111314625];

WOS:000905505200009

2-s2.0-85144800505

Scopus

1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
2.Department of Radiology,Shanghai General Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai,200080,China

Lu，Hongwei,Chen，An,Zhang，Xindan,et al. A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging[J]. Nature Communications,2022,13(1).

Lu，Hongwei.,Chen，An.,Zhang，Xindan.,Wei，Zixiang.,Cao，Rong.,...&Tian，Leilei.(2022).A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging.Nature Communications,13(1).

Lu，Hongwei,et al."A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging".Nature Communications 13.1(2022).