| 题名 | Identification and quantitative analysis of bioactive components from Potentilla kleiniana Wight et Arn with anti HIV-1 proteases activity |
| 作者 | |
| 通讯作者 | Zhou，Ying |
| 发表日期 | 2022
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| DOI | |
| 发表期刊 | |
| ISSN | 1478-6419
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| EISSN | 1478-6427
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| 摘要 | Potentilla kleiniana Wight et Arn（PK, ‘Wu Pi Feng’ in Chinese） was recorded as Miao ethnic medicine for treatment of fever, cough, ulcer, and erysipelas for thousands years. This study aimed to evaluate the antiviral activity of four PK extracts and seven compounds by using HIV-1 protease (HIV-1 PR). In addition, Ultra-High Performance Liquid Chromatography and High Resolution Mass Spectrometry (UPLC-HRMS) was employed to identify the bioactive components. The toxicity assessment of the extracts was done before antiviral screening using a highly specific human aspartyl protease, renin protease by fluorimetric method. As a result, seven compounds and four extracts of PK inhibited HIV-1 PR with IC range from 0.009 to 0.36 mg/mL, and did not appreciably inhibit the general human protease renin. This study first demonstrated that four PK extracts, ellagic acid and ursolic acid potent inhibit HIV-1 protease, could be used as an efficacious drug candidate to treat SARS-CoV-2 infection. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| WOS记录号 | WOS:000905820700001
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| ESI学科分类 | PHARMACOLOGY & TOXICOLOGY
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| Scopus记录号 | 2-s2.0-85145035132
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| 来源库 | Scopus
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| 引用统计 |
被引频次[WOS]：3
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/536940 |
| 专题 | 南方科技大学医学院_药理学系 南方科技大学第一附属医院 |
| 作者单位 | 1.College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang,China 2.Department of Pharmacology,Shenzhen People’s Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China 3.College of Pharmacy and Nutrition,University of Saskatchewan,Saskatoon,Canada |
| 推荐引用方式 GB/T 7714 |
Zhou，Yong Qiang,Li，Su Mei,Wei，Xin,et al. Identification and quantitative analysis of bioactive components from Potentilla kleiniana Wight et Arn with anti HIV-1 proteases activity[J]. Natural Product Research,2022.
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| APA |
Zhou，Yong Qiang.,Li，Su Mei.,Wei，Xin.,Yang，Xin.,Xiao，Jun Wei.,...&Wei，Ying.(2022).Identification and quantitative analysis of bioactive components from Potentilla kleiniana Wight et Arn with anti HIV-1 proteases activity.Natural Product Research.
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| MLA |
Zhou，Yong Qiang,et al."Identification and quantitative analysis of bioactive components from Potentilla kleiniana Wight et Arn with anti HIV-1 proteases activity".Natural Product Research (2022).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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