基于口腔正畸力测量的关键材料与装置研究

        口腔正畸是治疗错颌畸形的主要手段，其中正畸力测量对于临床正畸 诊疗有着重要的研究意义。正畸力测量可以为临床正畸医师提供更加可靠 和量化的正畸力数据，增强医师对相应治疗手段的理解，辅助改进正畸设 计方案。当前的正畸力测量装置中不包含牙周膜这一关键结构，导致测量 不精准，测量结果与临床实际差异较大。实现口腔正畸的精准诊疗需要提 升正畸力测试方法以及优化装置结构。传统的正畸力测量方法与装置已不 能满足当前精准个性化治疗需求，实现精准口腔正畸力测量是亟待解决的 关键问题。基于上述关键问题，本文建立一种更为符合人体口腔真实结构 环境的体外正畸力测试方法和装置。本文主要研究内容如下：

       为了得到易制备、杨氏模量可调控且能稳定合成的水凝胶作为仿牙周 膜材料，开展了正畸力测量方法以及水凝胶在仿生材料上应用的调研，并 对仿牙周膜水凝胶进行制备及性能影响分析。经过调研分析，决定选用聚 丙烯酰胺水凝胶作为仿牙周膜材料，采用温度固化的方法进行水凝胶的制 备。通过分析对单体、交联剂和引发剂对水凝胶材料力学性能的影响，得 到一种满足实验测试需要且可稳定制备的聚丙烯酰胺水凝胶材料配比。

      为了使牙颌结构更为符合真实人体口腔牙周结构环境，并提高正畸力 测量装置的合理性。本文采用基于患者真实口腔颌面锥形束电子计算机断 层扫描图和口腔内部扫描图建立牙颌三维模型，确保牙齿定位准确并留出 牙周膜的空间。制定正畸力测量方案，并优化正畸力测量装置的结构设计。

       最终目的是为了验证基于水凝胶牙周膜的体外正畸力测试方法与装置 的可靠性。以可稳定合成水凝胶材料的配比为基础，制备不同力学性能的 仿牙周膜水凝胶进行正畸力测量。经过正畸力测量，将正畸力测量的力和 位移曲线与已发表的在人体真实牙列上测量结果进行对比。结果表明，当 仿牙周膜水凝胶材料的杨氏模量为 0.78 MPa 时可很好模拟牙齿受力和移动。 进而验证了本文基于水凝胶仿牙周膜的正畸力测量方法的可靠性。

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