溶胶-凝胶硼酸盐生物玻璃骨水泥的制备 及理化性质和生物相容性研究

为了解决临床上应用的骨水泥降解速度慢，骨诱导性差的缺点，本研 究制备硼酸盐骨水泥，通过材料表征实验和生物学实验对硼酸盐生物玻璃 的结构和性能进行表征，选择出一种性能效果最好的硼酸盐生物玻璃，将 选择出硼酸盐生物玻璃与制备好的溶胶凝胶溶液进行不同比例的混合制备 出硼酸盐骨水泥，通过对固液比的调控对硼酸盐生物玻璃的理化性质和生 物活性进行测定，在其中选择出临床上应用效果最好的硼酸盐骨水泥。 使用溶胶-凝胶法制备掺杂不同比例的镁(Mg)和钠(Na)的硼酸盐生物玻 璃，对其进行 X 射线衍射分析，材料粒径分布分析，表面孔结构分析等一 系列材料学表征实验，对硼酸盐生物玻璃的物理化学性质进行研究。通过 离子释放性能测试，细胞活性检测，对硼酸盐生物玻璃的降解性能，生物 活性进行测定。使用透明质酸和柠檬酸制备好的溶胶凝胶溶液和硼酸盐生 物玻璃混合制备硼酸盐骨水泥，对其凝固情况，可注射效果，粘结性，力 学性能，降解性能，生物相容性进行全面测定和评价。 通过溶胶-凝胶法成功制备出硼酸盐生物玻璃，通过一系列材料学表征 实验及生物学实验，得出掺杂 Mg 的硼酸盐生物玻璃性能效果好于掺杂 Na 的硼酸盐生物玻璃，并且在当 Mg 含量为 5%和 10%时生物活性更好。制备 得到的硼酸盐骨水泥具有较好的可注射效果，粘结性，力学性能，降解性 能，生物相容性。综合所有结果，当固液比为 1:1.3 g/ml 时制备出掺 Mg 硼 酸盐骨水泥最符合临床上的要求。

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