Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease

Wang, Er-jin1; Wu, Ming-Yue2,3; Ren, Zheng-yu1; Zheng, Ying1; Ye, Richard D.4; Tan, Chris Soon Heng5; Wang, Yitao1; Lu, Jia-Hong1,6

2023

10.1093/burnst/tkad004

BURNS & TRAUMA   影响因子和分区

2321-3868

2321-3876

Inflammatory bowel disease (IBD) is a chronic, non-specific, recurrent inflammatory disease, majorly affecting the gastrointestinal tract. Due to its unclear pathogenesis, the current therapeutic strategy for IBD is focused on symptoms alleviation. Autophagy is a lysosome-mediated catabolic process for maintaining cellular homeostasis. Genome-wide association studies and subsequent functional studies have highlighted the critical role of autophagy in IBD via a number of mechanisms, including modulating macrophage function. Macrophages are the gatekeepers of intestinal immune homeostasis, especially involved in regulating inflammation remission and tissue repair. Interestingly, many autophagic proteins and IBD-related genes have been revealed to regulate macrophage function, suggesting that macrophage autophagy is a potentially important process implicated in IBD regulation. Here, we have summarized current understanding of macrophage autophagy function in pathogen and apoptotic cell clearance, inflammation remission and tissue repair regulation in IBD, and discuss how this knowledge can be used as a strategy for IBD treatment.

Autophagy Inflammatory bowel diseases Inflammation Tissue repair Efferocytosis Macrophage

SCI

英语

其他

Shenzhen Fundamental Research Program[SGDX20210823103804030] ; Science and Technology Development Fund, Macau SAR[0025/2022/A1] ; 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab)[2020B1212030006] ; Guangdong Basic and Applied Basic Research Foundation[2022A1515012416] ; National Natural Science Foundation of China[31871024] ; University of Macau[MYRG201900129-ICMS]

Emergency Medicine ; Dermatology ; Surgery

Emergency Medicine ; Dermatology ; Surgery

WOS:000981151900001

OXFORD UNIV PRESS

Web of Science

1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China
2.Third Mil Med Univ, Army Med Univ, Affiliated Hosp 1, Southwest Hosp,Dept Gastroenterol,Ctr Metab Liver, Chongqing 400038, Peoples R China
3.Third Mil Med Univ, Army Med Univ, Affiliated Hosp 1, Southwest Hosp,Ctr Cholestat Liver Dis,Dept Gastro, Chongqing 400038, Peoples R China
4.Chinese Univ Hong Kong, Kobilka Inst Innovat Drug Discovery, Sch Life & Hlth Sci, Shenzhen 518172, Peoples R China
5.Southern Univ Sci & Technol, Coll Sci, Dept Chem, Shenzhen 518055, Peoples R China
6.Univ Macau, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Macau, Peoples R China

Wang, Er-jin,Wu, Ming-Yue,Ren, Zheng-yu,et al. Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease[J]. BURNS & TRAUMA,2023,11.

Wang, Er-jin.,Wu, Ming-Yue.,Ren, Zheng-yu.,Zheng, Ying.,Ye, Richard D..,...&Lu, Jia-Hong.(2023).Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease.BURNS & TRAUMA,11.

Wang, Er-jin,et al."Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease".BURNS & TRAUMA 11(2023).