南方科技大学知识苑(SUSTech KC): Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6

题名	Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6
作者	Zhu, Xiaoqi 1; Shen, Junyan 1; Feng, Shengyu 1; Huang, Ce 1; Wang, Hao 1; Huo, Fengjiao 1; Liu, Hailiang 1,2,3
通讯作者	Liu, Hailiang
发表日期	2023-05-30
DOI	10.1186/s40168-023-01567-1
发表期刊	MICROBIOME 影响因子和分区
ISSN	2049-2618
EISSN	2049-2618
卷号	11 期号:1
摘要	Background Metformin, a type 2 diabetes treatment, improves the cognitive function of aged mice; however, whether the protective effects of metformin on cognitive function in aged mice are associated with the gut microbiome is poorly understood. Although some studies suggest that the gut microbe composition influences cognitive function and that manipulating the gut microbiota might protect against age-related cognitive dysfunction, there is no direct evidence to validate that the gut microbiota mediates the effect of metformin on cognitive improvement.Results In this study, we show that the gut microbiota is altered by metformin, which is necessary for protection against ageing-associated cognitive function declines in aged mice. Mice treated with antibiotics did not exhibit metformin-mediated cognitive function protection. Moreover, treatment with Akkermansia muciniphila, which is enriched by metformin, improved cognitive function in aged mice. Mechanistically, A. muciniphila decreased pro-inflammatory-associated pathways, particularly that of the pro-inflammatory cytokine interleukin (IL)-6, in both the peripheral blood and hippocampal profiles, which was correlated with cognitive function improvement. An IL-6 antibody protected cognitive function, and an IL-6 recombinant protein abolished the protective effect of A. muciniphila on cognitive function in aged mice.Conclusion This study reveals that A. muciniphila, which is mediated in the gut microbiota by metformin, modulates inflammation-related pathways in the host and improves cognitive function in aged mice by reducing the pro-inflammatory cytokine IL-6.
关键词	A. muciniphila Metformin Gut microbiota Cognitive function Inflammation IL-6
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	National Key Research and Development Program of China[2020YFC2002800] ; National Natural Science Foundation of China[82271593] ; Fundamental Research Funds for the Central University[22120210584]
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:001000080600001
出版者	BMC
Scopus记录号	2-s2.0-85160611701
来源库	Web of Science
引用统计	被引频次[WOS]：38
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/549058
专题	南方科技大学医学院_前沿生物技术研究院生命科学学院
作者单位	1.Tongji Univ, Shanghai East Hosp, Inst Regenerat Med, Sch Med, Shanghai 200123, Peoples R China 2.Shihezi Univ, Coll Life Sci, Key Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Shihezi 832003, Peoples R China 3.Southern Univ Sci & Technol, Inst Adv Biotechnol, Shenzhen 518055, Peoples R China
通讯作者单位	前沿生物技术研究院
推荐引用方式 GB/T 7714	Zhu, Xiaoqi,Shen, Junyan,Feng, Shengyu,et al. Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6[J]. MICROBIOME,2023,11(1).
APA	Zhu, Xiaoqi.,Shen, Junyan.,Feng, Shengyu.,Huang, Ce.,Wang, Hao.,...&Liu, Hailiang.(2023).Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6.MICROBIOME,11(1).
MLA	Zhu, Xiaoqi,et al."Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6".MICROBIOME 11.1(2023).