Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge

Ning, Shipeng1,2; Lyu, Meng3,4; Zhu, Daoming5,6; Lam, Jacky W. Y.7,8; Huang, Qinqin11; Zhang, Tianfu7,8,10; Tang, Ben Zhong7,8,9

2023-05-15

10.1021/acsnano.3c00326

ACS NANO   影响因子和分区

1936-0851

1936-086X

Cuproptosis shows good application prospects in tumor therapy.However, the copper efflux mechanism and highly expressed intracellularreducing substances can inhibit the cuproptosis effects. In this study,a platelet vesicle (PV) coated cuprous oxide nanoparticle (Cu2O)/TBP-2 cuproptosis sensitization system (PTC) was constructedfor multiple induction of tumor cuproptosis. PTC was prepared by physicalextrusion of AIE photosensitizer (TBP-2), Cu2O, and PV.After the biomimetic modification, PTC can enhance its long-term bloodcirculation and tumor targeting ability. Subsequently, PTC was rapidlydegraded to release copper ions under acid conditions and hydrogenperoxides in tumor cells. Then, under light irradiation, TBP-2 quicklyenters the cell membrane and generates hydroxyl radicals to consumeglutathione and inhibit copper efflux. Accumulated copper can causelipoylated protein aggregation and iron-sulfur protein loss,which result in proteotoxic stress and ultimately cuproptosis. PTCtreatment can target and induce cuproptosis in tumor cells in vitroand in vivo, significantly inhibit lung metastasis of breast cancer,increase the number of central memory T cells in peripheral blood,and prevent tumor rechallenge. It provides an idea for the designof nanomedicine based on cuproptosis.

cuproptosis type-I AIE photosensitizer copperefflux inhibition glutathione depletion tumormetastasis and rechallenge

SCI

英语

ESI高被引 ; NI论文

其他

Guangxi Clinical Research Center for Anesthesiology[GK AD22035214] ; Cultivation of High-level Internationalized Talents Project[22180007] ; Distinguished Talent Cultivation Program of Science and Technology Innovative[2020BJRCA02]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:001006628600001

AMER CHEMICAL SOC

Web of Science

1.Guangxi Med Univ, Canc Hosp, Nanning 530000, Peoples R China
2.Guangxi Clin Res Ctr Anesthesiol, Nanning 530000, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Dept Gastrointestinal Surg Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
4.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
5.Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg, Guangzhou 510515, Guangdong, Peoples R China
6.Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestinal, Guangzhou 510515, Guangdong, Peoples R China
7.Hong Kong Univ Sci & Technol Clear Water Bay, Hong Kong Branch Chinese Natl Engn Res Ctr Tissue, Dept Chem, Kowloon, Hong Kong 999077, Peoples R China
8.Hong Kong Univ Sci & Technol Clear Water Bay, Inst Adv Study, Hong Kong 999077, Peoples R China
9.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China
10.Guangzhou Med Univ, Sch Biomed Engn, Guangzhou 511436, Peoples R China
11.Zhengzhou Univ, Acad Med Sci, Precis Med Ctr, Daxuebei Rd 40, Zhengzhou 450052, Peoples R China

Ning, Shipeng,Lyu, Meng,Zhu, Daoming,et al. Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge[J]. ACS NANO,2023,17(11).

Ning, Shipeng.,Lyu, Meng.,Zhu, Daoming.,Lam, Jacky W. Y..,Huang, Qinqin.,...&Tang, Ben Zhong.(2023).Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge.ACS NANO,17(11).

Ning, Shipeng,et al."Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge".ACS NANO 17.11(2023).