| 题名 | Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells |
| 作者 | |
| 通讯作者 | Li, Rong; Liu, Xiao-Yu |
| 发表日期 | 2023-06-12
|
| DOI | |
| 发表期刊 | |
| ISSN | 1868-8497
|
| EISSN | 2730-6011
|
| 卷号 | 14期号:1 |
| 摘要 | Colon cancer is a common malignancy of the digestive tract. Colon cancer stem-like cells (CCSCs) are theoretically one of the key drivers of the initiation, relapse, metastasis, and chemo-resistance of colon tumors. Piezo1 is a mechanosensitive cationic channel protein involved in cancer progression. However, little is known regarding the possible role of Piezo1 in maintaining the stemness of CCSCs. In this study, we found that Piezo1 was highly expressed in CD133(+)/CD44(+) colon cancer tissues, and the Piezo1(high)/CD133(+)CD44(+) population was associated with the clinical stage. Furthermore, CCSCs isolated from colon cell lines expressed higher Piezo1 levels compared to the non-CCSCs, and Piezo1 knockdown inhibited their tumorigenicity and self-renewal capacity. Mechanistically, Piezo1 maintained the stemness of CCSCs through Ca2+/NFAT1 signaling, and knocking down Piezo1 promoted degradation of NFAT1. Taken together, Piezo1 is involved in the stage of colon cancer and is a promising therapeutic target. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 通讯
|
| 资助项目 | National Natural Science Foundation of China[82003108]
; Science and Technology Plan of Jiangxi Provincial Health and Family Planning Commission[202140804]
|
| WOS研究方向 | Oncology
; Endocrinology & Metabolism
|
| WOS类目 | Oncology
; Endocrinology & Metabolism
|
| WOS记录号 | WOS:001004953600001
|
| 出版者 | |
| Scopus记录号 | 2-s2.0-85161814007
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：7
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/549099 |
| 专题 | 南方科技大学医学院 |
| 作者单位 | 1.Ganzhou Canc Hosp, Dept Pathol, 19 HuaYuan Qian Rd, Ganzhou, Jiangxi, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, 1088 Xueyuan Ave, Shenzhen, Guangdong, Peoples R China |
| 通讯作者单位 | 南方科技大学医学院 |
| 推荐引用方式 GB/T 7714 |
Li, Rong,Wang, Dongmei,Li, Huijuan,et al. Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells[J]. DISCOVER ONCOLOGY,2023,14(1).
|
| APA |
Li, Rong,Wang, Dongmei,Li, Huijuan,Lei, Xianhua,Liao, Weilian,&Liu, Xiao-Yu.(2023).Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells.DISCOVER ONCOLOGY,14(1).
|
| MLA |
Li, Rong,et al."Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells".DISCOVER ONCOLOGY 14.1(2023).
|
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
; 
修改评论