Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids

Guo, Xing1,2; Li, Pengfei2; Liu, Han1; Li, Xuechen1

2023-06-01

10.1039/d3qo00637a

ORGANIC CHEMISTRY FRONTIERS   影响因子和分区

2052-4129

Bacteria resistant to antibiotics present a threat to public health. The bacterial non-2-ulosonic acids, including pseudaminic acid, legionaminic acid, acinetaminic acid, fusaminic acid, and several of their epimers, have been identified from the pathogenic Gram-negative bacteria, which have been proposed to associate with bacterial infection/pathogenicity, immune escape, and so on. The intriguing structures and less-understood biological functions make them attractive synthetic targets for biological studies and drug discovery. In this review, the chemical syntheses of four types of non-2-ulosonic acid structures that were reported in the past two decades are summarised, together with recent progress on the application of synthetic non-2-ulosonic acid derivatives.

SCI ; EI

英语

其他

Research Grants Council of Hong Kong["17312822","C7003-20G"] ; Health and Medical Research Fund[20190802]

Chemistry

Chemistry, Organic

WOS:001006241900001

ROYAL SOC CHEMISTRY

20232614320808

Bacteria ; Health risks

Health Care:461.7 ; Chemical Reactions:802.2

Web of Science

1.Univ Hong Kong, Dept Chem, State Key Lab Synthet Chem, Pokfulam Rd, Hong Kong, Peoples R China
2.Southern Univ Sci & Technol, Dept Chem, Shenzhen, Guangdong, Peoples R China

Guo, Xing,Li, Pengfei,Liu, Han,et al. Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids[J]. ORGANIC CHEMISTRY FRONTIERS,2023,10(13):3429-3446.

Guo, Xing,Li, Pengfei,Liu, Han,&Li, Xuechen.(2023).Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids.ORGANIC CHEMISTRY FRONTIERS,10(13),3429-3446.

Guo, Xing,et al."Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids".ORGANIC CHEMISTRY FRONTIERS 10.13(2023):3429-3446.