Near Infrared-Absorbing Nanoparticle-Mediated Endovascular Photothermal Precision Embolization of Tumor Feeding Vessels for Starvation Treatment

Xiao, Jingyu; Yang, Dishuang; Fang, Xiaofeng; Liu, Xiaoya; Liu, Xuezhe; Ma, Le; Wang, Ziyan; Wu, Changfeng; Guo, Qiongyu

2023-05-01

10.1021/acsbiomaterials.3c00287

ACS BIOMATERIALS SCIENCE & ENGINEERING   影响因子和分区

2373-9878

Photothermal therapy has attracted enormous attentionas an efficienttreatment modality in cancer ablation but still encounters a majorbottleneck due to the limited penetration depth of light inside tissues.To overcome the challenge of deep tissue penetration, we present astrategy of endovascular photothermal precision embolization (EPPE),which employs an endovascular optical fiber to induce local embolizationonly in the entrance of feeding vessels through photothermal heatingfor the purpose of fully blocking the blood supply of the whole tumor.In EPPE, we apply a highly efficient and biocompatible photothermalagent, i.e., near-infrared (NIR)-light-absorbing diketopyrrolopyrrole-dithiophene-basednanoparticle, which exhibits a high cell-killing efficacy at a concentrationof 200 & mu;g/mL using 808 nm laser irradiation of 0.5 W/cm(2) within 5 min in both 2D cell culture and a 3D tumor spheroidmodel. We verify the feasibility of EPPE in an ex vivo organ-structuredrecellularized liver model and further confirm the in vivo efficacyof the photothermal treatment in a rat liver model. The photothermaltreatment combined with the embolization effect holds promise to serveas an effective starvation therapy to treat tumors of varying sizesand locations.

photothermal therapy near-infrared-absorbing nanoparticles embolization deep tissue recellularization

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[81971764] ; Guangdong Research Fund[2019ZT08Y191] ; Key-Area Research and Development Program of Guangdong Province[2019B010941001] ; Innovation Committee of Shenzhen Municipality["JCYJ20200109141638004","JCYJ20210324115807021"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009]

Materials Science

Materials Science, Biomaterials

WOS:001012189300001

AMER CHEMICAL SOC

20232614306693

3D modeling ; Biocompatibility ; Blood vessels ; Cell culture ; Infrared devices ; Light absorption ; Optical fibers ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Immunology:461.9.1 ; Data Processing and Image Processing:723.2 ; Light/Optics:741.1 ; Fiber Optics:741.1.2 ; Nanotechnology:761 ; Solid State Physics:933

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Guangdong, Peoples R China

Xiao, Jingyu,Yang, Dishuang,Fang, Xiaofeng,et al. Near Infrared-Absorbing Nanoparticle-Mediated Endovascular Photothermal Precision Embolization of Tumor Feeding Vessels for Starvation Treatment[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2023,9(6):3660-3669.

Xiao, Jingyu.,Yang, Dishuang.,Fang, Xiaofeng.,Liu, Xiaoya.,Liu, Xuezhe.,...&Guo, Qiongyu.(2023).Near Infrared-Absorbing Nanoparticle-Mediated Endovascular Photothermal Precision Embolization of Tumor Feeding Vessels for Starvation Treatment.ACS BIOMATERIALS SCIENCE & ENGINEERING,9(6),3660-3669.

Xiao, Jingyu,et al."Near Infrared-Absorbing Nanoparticle-Mediated Endovascular Photothermal Precision Embolization of Tumor Feeding Vessels for Starvation Treatment".ACS BIOMATERIALS SCIENCE & ENGINEERING 9.6(2023):3660-3669.