Leveraging bimetallic nanoparticles to synergistically enhance the efficacy of antibiotics against carbapenem-resistant bacteria

Zhao, Xiaohui1,2; Liu, Shaoqin1; Jiang, Xingyu1,2

2023-05-01

10.1007/s40843-022-2459-3

SCIENCE CHINA-MATERIALS   影响因子和分区

2095-8226

2199-4501

Increasing resistance to carbapenem antibiotics has become a particular concern. Combination therapy might constitute an effective way to control drug-resistant bacterial infections. Here, we show that AuRh nanoparticles (NPs) have a synergistic antibacterial effect with a small-molecule antibiotic (imipenem), and they exhibit excellent antibacterial efficacies by increasing intracellular reactive oxygen species levels and enhancing the permeability of the bacterial membrane. In particular, the combination therapy restores the efficacy of imipenem against carbapenem-resistant Klebsiella pneumoniae (CRKP), with a 128-fold reduction in the minimum inhibitory concentration. In the treatment of lung infections, the combination of AuRh NPs (2 mg kg(-1)) and imipenem (2 mg kg(-1)) more effectively inhibits CRKP infection, with a 50% increase in the survival rate of mice compared with groups treated with imipenem or AuRh NPs alone. For in vitro and in vivo safety studies, AuRh NPs combined with imipenem show no significant toxicity, even at an injected concentration of 100 mg kg(-1) in mice. This combination therapeutic provides an effective treatment for drug-resistant bacterial infections.

antibiotic resistance combination therapy bimetallic nanoparticles antibiotics lung infection

SCI ; EI

英语

通讯

National Key R&D Program of China["2020YFA0908900","2018YFA0902600","2022YFB3804700","2021YFF1200100"] ; National Natural Science Foundation of China[22234004] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Science and Technology Program["KQTD20190929172743294","JCYJ20200109141231365"] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Natural Science Foundation of Shenzhen City[JCYJ20190809115005628] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191] ; Guangdong Major Talent Introduction Project[2019CX01Y196]

Materials Science

Materials Science, Multidisciplinary

WOS:001005423500001

SCIENCE PRESS

20232414218216

Bacteria ; Biological organs ; Mammals ; Nanoparticles

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Nanotechnology:761 ; Solid State Physics:933

Web of Science

1.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China

Zhao, Xiaohui,Liu, Shaoqin,Jiang, Xingyu. Leveraging bimetallic nanoparticles to synergistically enhance the efficacy of antibiotics against carbapenem-resistant bacteria[J]. SCIENCE CHINA-MATERIALS,2023,66(7):2885-2892.

Zhao, Xiaohui,Liu, Shaoqin,&Jiang, Xingyu.(2023).Leveraging bimetallic nanoparticles to synergistically enhance the efficacy of antibiotics against carbapenem-resistant bacteria.SCIENCE CHINA-MATERIALS,66(7),2885-2892.

Zhao, Xiaohui,et al."Leveraging bimetallic nanoparticles to synergistically enhance the efficacy of antibiotics against carbapenem-resistant bacteria".SCIENCE CHINA-MATERIALS 66.7(2023):2885-2892.