Effects of continuous renal replacement therapy on inflammation-related anemia, iron metabolism and prognosis in sepsis patients with acute kidney injury

An, Meng-meng1,2; Liu, Chen-xi2; Gong, Ping3

2023

10.5847/wjem.j.1920-8642.2023.052

WORLD JOURNAL OF EMERGENCY MEDICINE   影响因子和分区

1920-8642

BACKGROUND: This study aims to evaluate the effect of continuous renal replacement therapy (CRRT) on inflammation-related anemia, iron metabolism, and the prognosis in sepsis patients with acute kidney injury (AKI). METHODS: Sepsis patients with AKI were prospectively enrolled and randomized into the CRRT and control groups. The clinical and laboratory data on days 1, 3 and 7 after intensive care unit (ICU) admission were collected. The serum interleukin (IL)-6, hepcidin, erythropoietin, ferritin, and soluble transferrin receptor (sTfR) were determined by enzyme-linked immunosorbent assay. The Sequential Organ Failure Assessment (SOFA) score and 28-day mortality were recorded. Data were analyzed using Pearson's Chi-square test or Fisher's exact test (categorical variables), and Mann-Whitney U-test or t-test (continuous variables). RESULTS: The hemoglobin and serum erythropoietin levels did not signifi cantly diff er between the CRRT and control groups though gradually decreased within the first week of ICU admission. On days 3 and 7, the serum IL-6, hepcidin, ferritin, and red blood cell distribution width significantly decreased in the CRRT group compared to the control group (all P<0.05). On day 7, the serum iron was significantly elevated in the CRRT group compared to the control group (P<0.05). However, the serum sTfR did not signifi cantly diff er between the groups over time. In addition, the SOFA scores were signifi cantly lower in the CRRT group compared to the control group on day 7. The 28-day mortality did not signifi cantly diff er between the control and CRRT groups (38.0% vs. 28.2%, P=0.332) . CONCLUSION: CRRT might have beneficial effects on the improvement in inflammation -related iron metabolism and disease severity during the first week of ICU admission but not anemia and 28-day mortality in sepsis patients with AKI.

Sepsis Continuous renal replacement therapy Acute kidney injury Anemia Iron metabolism

SCI

英语

通讯

Shenzhen Key Medical Discipline Construction Fund[SZXK046] ; National Nature Science Foundation of China[81571869]

Emergency Medicine

Emergency Medicine

WOS:001003516500003

ZHEJIANG UNIV PRESS

Web of Science

1.Dalian Med Univ, Affiliated Dalian Friendship Hosp, Intens Care Unit, Dalian 116100, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dept Emergency Med, Dalian 116011, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Emergency Med,Clin Med Coll 2,Hosp 1, Shenzhen 518020, Peoples R China

An, Meng-meng,Liu, Chen-xi,Gong, Ping. Effects of continuous renal replacement therapy on inflammation-related anemia, iron metabolism and prognosis in sepsis patients with acute kidney injury[J]. WORLD JOURNAL OF EMERGENCY MEDICINE,2023,14(3).

An, Meng-meng,Liu, Chen-xi,&Gong, Ping.(2023).Effects of continuous renal replacement therapy on inflammation-related anemia, iron metabolism and prognosis in sepsis patients with acute kidney injury.WORLD JOURNAL OF EMERGENCY MEDICINE,14(3).

An, Meng-meng,et al."Effects of continuous renal replacement therapy on inflammation-related anemia, iron metabolism and prognosis in sepsis patients with acute kidney injury".WORLD JOURNAL OF EMERGENCY MEDICINE 14.3(2023).